PMID: 6166073Apr 1, 1981Paper

Intrapleural instillation of streptokinase. Effects on systemic fibrinolysis

The Thoracic and Cardiovascular Surgeon
E BerglinG William-Olsson

Abstract

Ten consecutive patients aged 25 to 75 with postoperative empyema or hemothorax conventionally treated with drainage without sufficient effect were given intrapleural instillations of streptokinase (Kabikinase, 250,000 IE) for 4 hours). The effects on systemic fibrinolysis were studied. Venous blood samples for determination of fibrinolytic activity on fibrin plates, plasminogen, alpha 2-antiplasmin, alpha 2-macroglobulin, fibrinogen, fibrin(ogen) degradation products (FDP) and thrombin time were taken before instillation, after instillation and then after 24 hours. Preinstillation values were compared to the values 4 and 24 hours after instillation with Student's paired t-test. There were no differences in fibrinolytic activity, alpha 2-macroglobulin and thrombin time. There was a slight increase in plasminogen, alpha 2-antiplasmin and fibrinogen, probably due to an acute phase reaction. Fibrin degradation products showed an increase with border line significance. These changes are not consistent with generalized fibrinolysis, and it is concluded that intrapleural instillations of streptokinase can be given safely in the early posttraumatic or postoperative period.

Citations

Apr 1, 1993·The American Review of Respiratory Disease·C StrangeS A Sahn
Jun 14, 2000·AJR. American Journal of Roentgenology·J R HaagaM Bellmore
May 12, 2005·European Journal of Radiology·Orhan S OzkanOkan Akhan
Jun 1, 1995·Chest·G P LeMenseS A Sahn
Nov 1, 1990·The American Journal of the Medical Sciences·S K Willsie-EdigerM G Foreman
Jul 27, 2010·Pharmacotherapy·Susan E Hamblin, Douglas L Furmanek
May 1, 1991·American Journal of Surgery·R W AyeL D Hill
Jun 1, 1982·Clinical Physiology·R EkrothG William-Olsson
Apr 15, 2000·Radiologic Clinics of North America·J S Moulton
Oct 12, 1999·Clinics in Chest Medicine·J E Heffner
Apr 1, 1994·The Annals of Thoracic Surgery·L A RobinsonT A Galbraith
Oct 4, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joaquín DueñasJuan L Pérez-Navero
Jun 26, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·S T Lindstrom, J Kolbe
Dec 23, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Steven E MutsaersSteven Idell
Sep 1, 1989·British Heart Journal·J H CrossE D Silove
Mar 9, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joel B CochranRonald B Turner
Sep 1, 1994·Thorax·R F TaylorN C Barnes
Sep 29, 2017·Journal of Bronchology & Interventional Pulmonology·Radhika M ShahAshutosh Sachdeva
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·C W DaviesR J Davies
Mar 27, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Joel B CochranRonald B Turner
Dec 16, 2010·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Ala Eldin H Ahmed, Tariq E Yacoub
Jul 24, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anna C BibbyNick A Maskell
Dec 12, 2003·The Annals of Thoracic Surgery·Cemal OzcelikSerdar Onat
Jan 1, 1997·Current Problems in Diagnostic Radiology·C L SistromS B Gay
Jun 25, 2020·Reviews on Recent Clinical Trials·Maria Teresa CongedoMariano Alberto Pennisi
Aug 18, 2021·Respiratory Medicine Case Reports·Aleksandr Kalininskiy, Justin M Weis
Aug 23, 2021·Journal of Cardiothoracic Surgery·Awrad NasrallaSimon R Turner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gynecologic and Obstetric Investigation
G A DunselmanJ L Evers
The Annals of Otology, Rhinology, and Laryngology
T KosugiH Mihara
American Journal of Respiratory and Critical Care Medicine
C W DaviesR J Davies
The British Journal of Surgery
I M MacintyreC V Ruckley
© 2021 Meta ULC. All rights reserved