Intrapleural topical application of cisplatin with the surgical carrier Vivostat increases the local drug concentration in an immune-competent rat model with malignant pleuromesothelioma

The Journal of Thoracic and Cardiovascular Surgery
D LardinoisW Weder

Abstract

We sought to investigate whether intrapleural topical application of cisplatin with a surgical carrier has a prolonged local tissue level in comparison with cisplatin solution while reducing systemic toxicity. Forty immune-competent Fischer rats were inoculated with 10(6) mesothelioma cells. Ten days later, left pneumonectomy with tumor debulking was performed. Twenty animals underwent local application of cisplatin solution (100 mg/m2), whereas the same quantity of cisplatin was topically applied as a gel with the Vivostat (Vivolution) system in 20 other animals. In each group 5 subgroups of 4 animals were defined according to the harvesting time of blood and tissue samples (2, 4, 24, and 72 hours and 1 week) after local therapy. Platinum concentrations in serum and tissue and systemic toxicity were analyzed. Platinum concentrations in tissue were significantly higher in the gel group (group 1) than in the solution group (group 2) at 1, 3, and 7 days after therapy (1510, 1224, and 1069 pg/mg for group 1 vs 598, 382, and 287 pg/mg for group 2; P = .007, P = .005, and P = .0002, respectively). Laboratory findings showed renal insufficiency in the animals of the solution group at 1 week, with values of 98 mmol/L versus 7.7 mmol/L...Continue Reading

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Citations

Sep 16, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Nancy E MartinDavid H Abramson
Dec 3, 2013·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Shinichi OzakiNoboru Motomura
Feb 9, 2012·World Journal of Surgical Oncology·Olivier FacyAlain Bernard
Feb 24, 2016·Surgical Neurology International·Francesca GrazianoDomenico Gerardo Iacopino
Dec 21, 2010·The Journal of Thoracic and Cardiovascular Surgery·Isabelle OpitzWalter Weder
Jan 14, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jun ZhongMichael Roth
Apr 22, 2009·The Journal of Thoracic and Cardiovascular Surgery·Leonard M RademakersJos G Maessen
Dec 19, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Feng ChaiHartmut F Hildebrand
May 20, 2015·Surgical Neurology International·Francesca GrazianoDomenico G Iacopino
Oct 27, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mayura MeerangIsabelle Opitz
Aug 3, 2007·Journal of Environmental Monitoring : JEM·Michael Krachler
May 14, 2020·Mini Reviews in Medicinal Chemistry·Mohsen DoostmohammadiSeeram Ramakrishna
Jan 24, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zeinab Y Al SubehNicholas H Oberlies

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