PMID: 8946344Nov 6, 1996Paper

Intraportal infusion of 2,5-anhydro-D-mannitol increases afferent activity in the common hepatic vagus branch

Journal of the Autonomic Nervous System
T A LutzE Scharrer

Abstract

Peripheral administration of the fructose analogue 2,5-anhydro-D-mannitol (AM), that inhibits hepatic glucose release and ATP formation, stimulates food intake in rats. This effect is partly generated in the hepato-portal area and transmitted to the central nervous system by the common hepatic vagus branch because hepatic branch vagotomy eliminated the feeding response to AM. In the present study, we investigated if the pertinent signal to increase food intake changes the discharge rate in hepatic vagal afferents. An in vivo preparation was used to record afferent hepatic vagal activity following intraportal infusion of AM in anaesthetized rats. Fine nerve filaments were isolated from the distal cut end of the hepatic vagus branch. Nerve activity was recorded by a bipolar electrode and analyzed after conversion of raw data to standard pulses. Standard pulses were integrated into spike counts of 5 s duration and the mean number of spikes in a 50 s interval at baseline was compared to spike count 10, 30 and 50 min after infusion of AM (100 or 300 mg/kg) or saline (control). Saline infusion did not influence afferent hepatic vagal activity. Intraportal infusion of AM, however, dose-dependently increased afferent activity in the he...Continue Reading

References

Mar 1, 1990·Experimental Physiology·E Delprete, E Scharrer
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P T RiquelmeH A Lardy
Jun 30, 1985·Biochimica Et Biophysica Acta·H C StevensW L Dills
May 15, 1969·Annals of the New York Academy of Sciences·A Niijima
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P T RiquelmeH A Lardy
Dec 1, 1994·Journal of the Autonomic Nervous System·H NakabayashiR Takeda
Jan 1, 1994·Journal of the Autonomic Nervous System·E Del Prete, E Scharrer

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Citations

Nov 19, 2003·European Journal of Pharmacology·Gertjan van DijkAnton J W Scheurink
Feb 8, 2003·Journal of Neuroscience Methods·Charles C Horn, Mark I Friedman
Jun 19, 2012·The Proceedings of the Nutrition Society·Michael S Allen, Barry J Bradford
Dec 25, 2007·Annual Review of Psychology·Hans-Rudolf Berthoud, Christopher Morrison
Sep 30, 2006·The Journal of Reproduction and Development·Mohammad ShahabKei-ichiro Maeda
Sep 21, 2011·The Journal of Endocrinology·Lei HuangShigong Zhu
Jun 23, 2009·Appetite·Michael S Allen, Barry J Bradford
Feb 20, 2009·Obesity·Natalie R Lenard, Hans-Rudolf Berthoud
Sep 16, 2003·Biochimica Et Biophysica Acta·Nancy E RawsonMark I Friedman
Mar 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charles C Horn, Mark I Friedman
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Hans-Rudolf Berthoud
Dec 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wolfgang LanghansMyrtha Arnold
May 14, 2005·Endocrinology·Yukari DateMasamitsu Nakazato
Dec 20, 2002·Canadian Journal of Physiology and Pharmacology·Jean-Marc Lavoie
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·L BenthemA J Scheurink

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