Abstract
The purpose of this study was to assess the prognostic impact of intraprocedural thrombotic events (IPTE) during percutaneous coronary intervention (PCI). Ischemic complications of PCI are infrequent but prognostically important. How often these events are a consequence of intraprocedural complications is unknown, with only limited data assessing the occurrence and importance of IPTE. A total of 3,428 patients who underwent PCI for non-ST-segment elevation acute coronary syndrome in the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial underwent detailed frame-by-frame core laboratory angiographic analysis. An IPTE, defined as the development of new or increasing thrombus, abrupt vessel closure, no reflow, slow reflow, or distal embolization at any time during the procedure, occurred in 121 patients (3.5%). Patients with IPTE had higher in-hospital, 30-day, and 1-year major adverse cardiac event rates than patients without IPTE (25.6% vs. 6.3% in-hospital, 30.6% vs. 9.3% at 30 days, and 37.0% vs. 20.5% at 1 year; p < 0.0001 for each). An IPTE was strongly associated with Q-wave myocardial infarction and out-of-laboratory definite/probable stent thrombosis (in-hospital 3.3% vs. 0.5%, p = 0.006; 30 days...Continue Reading
References
Nov 4, 2004·American Heart Journal·Gregg W StoneHarvey D White
Nov 25, 2006·The New England Journal of Medicine·Gregg W StoneUNKNOWN ACUITY Investigators
Feb 14, 2007·The New England Journal of Medicine·Gregg W StoneMartin B Leon
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Apr 2, 2008·Lancet·Stephen D WiviottUNKNOWN TRITON-TIMI 38 Investigators
Jan 19, 2010·Lancet·Christopher P CannonUNKNOWN PLATelet inhibition and patient Outcomes Investigators
May 28, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Paul FeferAmit Segev
Jul 8, 2010·International Journal of Cardiology·Timm BauerAnselm K Gitt
Citations
Jun 14, 2013·Journal of Neurointerventional Surgery·Ronil V Chandra
Jun 21, 2013·Trials·Suzanne de WahaHolger Thiele
Jan 23, 2014·Cardiovascular Intervention and Therapeutics·Takahide KodamaEloisa Arbustini
Feb 25, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Sorin J BrenerGregg W Stone
Jun 13, 2014·Thrombosis and Haemostasis·T MaedaS Miyata
May 25, 2015·JACC. Cardiovascular Interventions·Gregg W StoneUNKNOWN CANARY Investigators
May 14, 2014·Thrombosis Research·Michio MizobeHisao Ogawa
Nov 9, 2014·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Eftal Murat BakirciErgun Topal
Nov 20, 2015·European Heart Journal. Acute Cardiovascular Care·Roza Meyer-SaraeiHolger Thiele
May 10, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Margaret McEntegartColin Berry
Apr 9, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Colin BerryPeter McCartney
Jul 12, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Eun Kyoung KimSeung Woo Park
Sep 12, 2018·European Heart Journal·Gregg W StoneDeepak L Bhatt
Oct 5, 2014·The International Journal of Cardiovascular Imaging·Giancarla ScaloneManel Sabaté
Mar 3, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Stephanie PlentGregg W Stone
Jul 20, 2014·Heart and Vessels·Tadatsugu GamouMasakazu Yamagishi
Jun 23, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Michael J Lipinski, Lowell F Satler
May 5, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hector TamezUNKNOWN CHAMPION PHOENIX ECONOMICS Investigators
Jan 25, 2016·JACC. Cardiovascular Interventions·Jeffrey D WesslerAjay J Kirtane
Sep 13, 2014·Journal of the American College of Cardiology·Holger ThieleIngo Eitel
Mar 13, 2014·The American Journal of Cardiology·Vijay KunadianC Michael Gibson