Intraprostatic lymphocyte profiles in aged wistar rats with estradiol induced prostate inflammation

The Journal of Urology
E V VykhovanetsSusan Ruth Marengo

Abstract

We report LS phenotypes in aged Wistar rats (Charles Rivers, Wilmington, Massachusetts) with EPI. EPI was induced in 36 to 40-week-old male rats by castration with subcutaneous injections of 17beta-estradiol (0.25 mg/kg daily) plus dihydrotestosterone propionate (2.5 mg/kg daily) in sesame oil for 30 days. Controls were sham castrated, aged rats that were injected with sesame oil. Prostate, spleen and blood LSs in aged and young (10 to 12-week-old) rats were identified by flow cytometry in a cluster of differentiation system. All prostates in 6, 17beta-estradiol plus dihydrotestosterone propionate treated rats and in 3 of 7 controls (43%) showed inflammation foci. All studied LSs in Aged-SPIs and Aged-EPIs were similar. Blood LSs in Aged-SPIs, Aged-EPIs, Aged-NPIs and Youngs showed no differences. Levels of lymphocytes bearing the natural killer marker were decreased, and levels of total T and CD4(+) T cells were increased in prostates with age. Intraprostatic and splenic levels of CD4(+) natural killer T cells were down-regulated significantly in Aged-SPIs and Aged-EPIs compared to those in Aged-NPIs and Youngs. Levels of CD45RC(+)CD4(+)alphabetaTCR(+) T cells were decreased 2-fold in the spleen and up-regulated 2-fold in the ...Continue Reading

References

Apr 1, 1994·The Journal of Experimental Medicine·T Yoshimoto, W E Paul
Mar 21, 1998·The Journal of Urology·M M CollinsM J Barry
Mar 2, 1999·The Journal of Experimental Medicine·B Seddon, D Mason
Sep 9, 2000·Annals of Internal Medicine·M McNaughton CollinsT J Wilt
Oct 11, 2003·Andrologia·A J Schaeffer
Mar 25, 2004·Nature Reviews. Immunology·Dale I GodfreyLuc Van Kaer

❮ Previous
Next ❯

Citations

Jun 12, 2009·International Journal of Andrology·Emrah YatkinRisto Santti
Jan 3, 2007·Prostate Cancer and Prostatic Diseases·E V VykhovanetsS Gupta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

© 2021 Meta ULC. All rights reserved