Intraprostatic spermatozoa: zonal distribution and association with atrophy

Human Pathology
Xiaoli ChenFernando U Garcia

Abstract

Intraprostatic spermatozoa (IS) have been demonstrated in only 2 articles in the literature reporting on postmortem prostates. Intraprostatic spermatozoa have not been previously described in radical prostatectomies. This is the first study that describes the presence of IS in radical prostatectomies with prostatic carcinoma (PC) and its association with atrophy. We examined whole mount sagittal sections from 69 consecutive radical prostatectomy cases for PC. A central section including the seminal vesicle ejaculatory duct urethra complex (SVEDU) from each case was stained with Berg's stain to identify spermatozoa and their location. The extent and the type of atrophy were assessed on the entire prostate by using a grid method. Eighteen cases (26.1%) revealed spermatozoa both in the SVEDU and in the prostate (IS) (group 1). Twenty-two cases (31.9%) showed spermatozoa exclusively in the SVEDU but not in the prostate (group 2). The remaining 29 cases (42.0%) had no spermatozoa in either site. Location of IS was 72.2% peripheral zone, 22.2% central zone, and 5.6% transitional zone. Intraprostatic spermatozoa were frequently seen accompanied by inflammatory infiltrate in the periglandular stroma. The extent of atrophy was greater i...Continue Reading

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Citations

Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
May 15, 2013·Nature Reviews. Urology·Panikar Wadhera
Jul 11, 2018·The Prostate·Ryan Butel, Richard Ball
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fernando U GarciaChristian Sell

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