PMID: 16641467DOI: 10.1128/aac.50.5.1878-1880.2006Apr 28, 2006Paper
Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen.
Antimicrobial Agents and Chemotherapy
Blair CapitanoRaman Venkataramanan
Abstract
Voriconazole penetrated well into the pulmonary epithelial lining fluid (ELF) in lung transplant patients receiving oral prophylaxis. The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/-8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted.
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