Intrarenal activation of endothelin type B receptors improves kidney oxygenation in type 1 diabetic rats

American Journal of Physiology. Renal Physiology
Stephanie FranzénFredrik Palm

Abstract

About one-third of patients with type 1 diabetes develops kidney disease. The mechanism is largely unknown, but intrarenal hypoxia has been proposed as a unifying mechanism for chronic kidney disease, including diabetic nephropathy. The endothelin system has recently been demonstrated to regulate oxygen availability in the diabetic kidney via a pathway involving endothelin type A receptors (ETA-R). These receptors mainly mediate vasoconstriction and tubular sodium retention, and inhibition of ETA-R improves intrarenal oxygenation in the diabetic kidney. Endothelin type B receptors (ETB-R) can induce vasodilation of the renal vasculature and also regulate tubular sodium handling. However, the role of ETB-R in kidney oxygen homeostasis is unknown. The effects of acute intrarenal ETB-R activation (sarafotoxin 6c for 30-40 min; 0.78 pmol/h directly into the renal artery) on kidney function and oxygen metabolism were investigated in normoglycemic controls and insulinopenic male Sprague-Dawley rats administered streptozotocin (55 mg/kg) 2 wk before the acute experiments. Intrarenal activation of ETB-R improved oxygenation in the hypoxic diabetic kidney. However, the effects on diabetes-induced increased kidney oxygen consumption coul...Continue Reading

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Mar 5, 2016·American Journal of Physiology. Renal Physiology·Stephanie FranzénFredrik Palm

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Citations

Jan 24, 2018·American Journal of Physiology. Renal Physiology·Samuel N HeymanZaid Abassi
Nov 18, 2019·Endocrine Regulations·Dmytro O MinchenkoOleksandr H Minchenko
Mar 22, 2019·Analytical and Bioanalytical Chemistry·Hilde-Marléne BergmanIngela Lanekoff
Nov 3, 2020·American Journal of Physiology. Renal Physiology·Regina F SultanovaDaria V Ilatovskaya

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Methods Mentioned

BETA
protein assay

Software Mentioned

GraphPad
GraphPad Prism

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