Intrarenal and extrarenal autonomic nervous system redefined

The Journal of Urology
Achim LuschJaime Landman

Abstract

The autonomic nervous supply to the kidneys is involved in the development of several diseases including hypertension. The neural distribution at the segmental vessels and intrarenal vasculature has not been well characterized. Thus, we evaluated the autonomic nerve distribution from the great vessels to the renal cortex in a cadaveric model. We performed a detailed anatomical nerve dissection from the inferior mesenteric artery to the renal operculum in 2 human cadaveric torsos. Autonomic nerve fibers were verified by dissecting the greater splanchnic, sympathetic trunk and ganglia. We then systematically cross-sectioned the kidneys in 12, 1 mm slices across 3.6 cm, and stained the slices for histopathological analysis of neural tissue in relation to segmental arteries and other anatomical landmarks. Advanced reconstructive software was used to create a 3-dimensional computer image. Autonomic nerve fibers are located almost exclusively anteriorly on the main renal arteries and segmental arteries, and are absent from veins. Histopathology revealed that the intrarenal nerves continued to track exclusively with the arteries but were more circumferentially distributed. There is minimal nerve tissue around the veins. Many nerves we...Continue Reading

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Citations

Apr 20, 2016·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Blanca MompeoJose Sanudo
Sep 19, 2014·Cardiovascular and Interventional Radiology·Eric de KervilerCédric de Bazelaire
Jul 16, 2016·Urology Case Reports·Victor SrougiLuis Yu
May 21, 2018·Current Hypertension Reports·Costas TsioufisDimitrios Tousoulis
Feb 18, 2021·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Nachiket J Patel, Richard R Heuser

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