Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells

Journal of the American Society of Nephrology : JASN
Kristy L EdgttonA Richard Kitching

Abstract

Dendritic cells in the kidney take up antigens, but little is known about their role in providing co-stimulatory signals for the activation of CD4(+) cells. This study examined the phenotype of dendritic cells in the renal interstitium and in the lymph node draining the kidney before and after intrarenal ovalbumin injection. After intrarenal injection of the antigen, expression of the co-stimulatory molecules CD86 and programmed cell death ligand 1 (PD-L1) increased on renal dendritic cells, whereas expression of only CD86 increased on dendritic cells of the draining lymph node. The activation and proliferation of antigen-specific CD4(+) cells in the lymph node were assessed by transfer of naïve, fluorescently labeled ovalbumin-specific T cell receptor transgenic cells to mice before antigen administration. Blocking both CD86 and CD80 profoundly inhibited CD4(+) cell proliferation, but CD86 was the dominant CD28 ligand in the early proliferative response of CD4(+) cells. Conversely, activation of PD-1, the receptor expressed on CD4(+) cells that binds PD-L1 and PD-L2, reduced the proliferation of CD4(+) cells in the draining lymph node. Comparing subcutaneous and intrarenal administration of antigen, it was found that CD4(+) ce...Continue Reading

References

Sep 1, 1994·Immunity·J M GreenC B Thompson
May 2, 1994·Journal of Immunological Methods·A B Lyons, C R Parish
Sep 5, 1998·Immunity·J J BirdS L Reiner
Aug 24, 1999·Immunology and Cell Biology·N L Harris, F Ronchese
Mar 10, 2001·Nature·R L ReinhardtM K Jenkins
Mar 13, 2001·Annual Review of Immunology·M K JenkinsK A Pape
Mar 13, 2001·Annual Review of Immunology·B Salomon, J A Bluestone
Apr 27, 2001·Trends in Immunology·H Nishimura, T Honjo
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohide YamazakiHideo Yagita
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jody L Bonnevier, Daniel L Mueller
Jul 9, 2003·The Journal of Experimental Medicine·Alan D SalamaSamia J Khoury
Jan 9, 2004·Nature·Thorsten R MempelUlrich H Von Andrian
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Thilo KrügerChristian Kurts
Sep 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Roland SchoopRudolf P Wüthrich
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Jun 10, 2005·Journal of the American Society of Nephrology : JASN·Dragana OdobasicStephen R Holdsworth
Oct 18, 2005·Molecular and Cellular Biology·Richard V ParryJames L Riley
Feb 17, 2007·Nature Immunology·Arlene H SharpeGordon J Freeman

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Citations

Feb 11, 2012·Nephrology·Simon Alexander TeterisChristian Kurts
Oct 13, 2009·Journal of the American Society of Nephrology : JASN·Shaun A SummersA Richard Kitching
Mar 20, 2010·Journal of the American Society of Nephrology : JASN·Poh-Yi GanStephen R Holdsworth
Dec 3, 2011·Journal of the American Society of Nephrology : JASN·Peter J NelsonJeremy Duffield
Apr 18, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A Richard Kitching
Mar 23, 2011·Seminars in Immunopathology·Dianne B McKay
Mar 12, 2009·Nephron. Experimental Nephrology·Peter VelázquezPeter J Nelson
Dec 18, 2009·Kidney International·Philipp EllerAlexander R Rosenkranz
May 27, 2011·Kidney International·Simon A TeterisChristian Kurts
Aug 5, 2010·International Journal of Experimental Pathology·Katharina HochheiserChristian Kurts
Oct 3, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ulf Panzer, Christian Kurts
Mar 16, 2013·Journal of the American Society of Nephrology : JASN·Jana Pindjakova, Matthew D Griffin
Feb 23, 2018·Nature Communications·Clare L V WesthorpeMichael J Hickey
Dec 26, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuan H YangMichael J Hickey
Feb 19, 2021·Cell and Tissue Research·Jan-Hendrik RiedelUlf Panzer

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