Intraretinal and periretinal pathology in anterior proliferative vitreoretinopathy.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
David G CharterisPhilip J Luthert

Abstract

To determine the intraretinal and periretinal pathological changes in early anterior proliferative vitreoretinopathy (APVR). Observational case series. Eighteen patients undergoing retinectomy for APVR. Retinectomy specimens removed at vitrectomy surgery were analysed by (a) semithin light microscopy, (b) immunohistochemistry and (c) electron microscopy. The specimens showed consistent outer retinal degenerative changes, marked Muller cell hypertrophy and glial continuity to epiretinal membranes. Photoreceptor outer and inner segments were markedly disrupted and occasional photoreceptor nuclear had pyknosis and chromatin clumping consistent with apoptosis. Muller cells expressed upregulated levels of glial fibrillary acid protein (GFAP) and extended through glial bridges to complex epiretinal membranes which in some areas had a bilaminar structure with a glial-negative inner lamina. Retinal degeneration and photoreceptor apoptosis occur in retinal detachment complicated by proliferative vitreoretinopathy (PVR), although during the early stages of the process neural retinal cells remain present, suggesting potential for recovery. The intraretinal glial response appears to be centrally involved in the formation of contractile epi...Continue Reading

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Citations

May 6, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Andreas Bringmann, Peter Wiedemann
May 13, 2008·Investigative Ophthalmology & Visual Science·Mark R VerardoSteven K Fisher
Apr 18, 2009·Seminars in Ophthalmology·Yannek I Leiderman, Joan W Miller
May 15, 2012·Current Eye Research·Fredrik Ghosh, Kristina Johansson
Aug 19, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Anselm Gerhard Maria JünemannAxel Petzold
Nov 30, 2013·Mediators of Inflammation·Vito RomanoMario R Romano
Aug 23, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Brijesh TakkarRohan Chawla
Jul 7, 2014·Journal français d'ophtalmologie·F Rouberol, C Chiquet
Jul 12, 2014·Journal français d'ophtalmologie·C Chiquet, F Rouberol
Sep 17, 2011·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Andreas Bringmann, Peter Wiedemann
Nov 1, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mario R RomanoGilda Cennamo
Apr 4, 2019·PloS One·Souska ZandiJustus G Garweg
May 16, 2020·Investigative Ophthalmology & Visual Science·Sun Young LeeRaju V Rajala
Jul 30, 2014·International Journal of Molecular Medicine·Yun Sun, Zhi-Peng You
Mar 19, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marc VeckeneerJan C van Meurs
Jun 25, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mario R RomanoGiovanni Cennamo
Aug 31, 2019·Journal of Ophthalmology·Rino FrisinaGiandomenico Nollo
Dec 17, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S GrisantiL Hattenbach

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