Intraruminal infusion of oligofructose alters ruminal microbiota and induces acute laminitis in sheep

Journal of Animal Science
H LiShengyong Mao


The objectives of this study were to examine the clinical response, changes in ruminal bacterial microbiota, and inflammatory response in lamellar tissues during oligofructose-induced laminitis. Ten fistulated sheep were randomly assigned into a control group ( = 5) and a treatment group ( = 5). The treatment group was infused with oligofructose (21 g/kg BW) by rumen cannula, and the control group was sham-treated with saline. Results showed that all 5 sheep treated with oligofructose developed anorexia and diarrhea 8 to 12 h after the administration of oligofructose. By 12 to 24 h after treatment, the treatment group developed lameness and roach back. Compared with the control group, oligofructose administration decreased ( < 0.001) the rumen pH and concentrations of total VFA and increased ( < 0.001) the level of lactic acid in the rumen. Microbial data analysis revealed that oligofructose infusion increased the abundance of ( = 0.009) and ( = 0.008) and decreased the percentage of unclassified Christensenellaceae ( = 0.028), unclassified Ruminococcaceae ( = 0.009), ( = 0.016), unclassified Lachnospiraceae ( = 0.009), and ( = 0.009) compared with the control group. Oligofructose infusion decreased the ACE ( = 0.047) and Shann...Continue Reading


Mar 1, 1986·Equine Veterinary Journal·M Yelle
Dec 1, 1982·European Journal of Clinical Microbiology·W W NicholsK Nicholls
Jun 1, 1981·Nihon juigaku zasshi. The Japanese journal of veterinary science·K Takahashi, B A Young
Aug 1, 1996·Journal of Dairy Science·J B Russell, D B Wilson
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·M J MüllerO Selberg
May 1, 1997·Journal of Dairy Science·J E Nocek
Feb 17, 1998·Journal of Animal Science·F N OwensD R Gill
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Seiki
Jun 5, 1999·Cancer Chemotherapy and Pharmacology·D E Kleiner, W G Stetler-Stevenson
Mar 10, 2001·Veterinary Microbiology·B A MungallChristopher C Pollitt
Feb 19, 2003·Research in Veterinary Science·S R BaileyJ Elliott
Apr 5, 2003·Applied and Environmental Microbiology·S R BaileyJ Elliott
May 19, 2004·Equine Veterinary Journal·S R Bailey
Sep 18, 2004·Journal of Dairy Science·M B ThoefnerP H Andersen
Jun 15, 2005·FEMS Microbiology Letters·R A M Al JassimChristopher C Pollitt
Dec 8, 2005·Applied and Environmental Microbiology·Catherine Lozupone, Rob Knight
May 19, 2006·Equine Veterinary Journal·A W van Eps, Christopher C Pollitt
Jul 6, 2006·Applied and Environmental Microbiology·Todd Z DeSantisG L Andersen
May 23, 2007·Journal of Dairy Science·T G Nagaraja, E C Titgemeyer
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Jan 19, 2008·Parasitology Research·Hong Yin, Jianxun Luo
Jan 24, 2009·Journal of Dairy Science·A M DanscherM B Thoefner
Apr 21, 2009·Molecular Biology and Evolution·Morgan N PriceAdam P Arkin
Nov 17, 2009·Bioinformatics·J Gregory CaporasoRob Knight
Jan 26, 2010·Equine Veterinary Journal·A W van Eps, Christopher C Pollitt
Aug 17, 2010·Bioinformatics·Robert C Edgar
Sep 21, 2010·Applied and Environmental Microbiology·S C FernandoU Desilva
Nov 15, 2011·Genome Biology·Gillian Murphy
Jun 7, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Junhua LiuShengyong Mao

Related Concepts

Lameness, Animal

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.