PMID: 2512034Mar 1, 1989Paper

Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma

Clinical Endocrinology
J S BevanC W Burke

Abstract

A 74-year-old acromegalic found to have an intrasellar gangliocytocytoma and GH-secreting pituitary adenoma is described. The gangliocytoma contained immunoreactive gastrin and, to a lesser extent, GHRH, and the adenoma immunostained for GH. Gastrin has not been previously reported in hypothalamic gangliocytomas. Since this peptide has been demonstrated in normal hypothalamus and pituitary, and provokes GH release when administered intraventricularly, it may have caused GHRH release from the gangliocytoma by a local paracrine action and led to adenoma formation and acromegaly.

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Citations

Jan 1, 1990·Acta Neuropathologica·F SlowikK Lapis
Mar 8, 2003·Brain Tumor Pathology·Masamichi KurosakiDieter K Lüdecke
Jul 13, 2002·Endocrine Pathology·Ikuo KobayashiKiyotaka Fujii
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Jan 16, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hidetoshi Ikeda, Shinobu Takayasu
Aug 16, 2016·Clinical Neurology and Neurosurgery·Giulia CossuMahmoud Messerer
Jan 13, 2017·The American Journal of Surgical Pathology·Camille SergeantChiara Villa
Nov 1, 1996·Clinical Pediatrics·J F Sotos
Nov 1, 2018·The American Journal of Surgical Pathology·Sylvia L AsaOzgur Mete
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Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·E A Eugster, O H Pescovitz
Feb 1, 1990·Clinical Endocrinology·J F Rehfeld, L Bardram
Oct 23, 2019·Journal of Clinical Medicine·Sylvia L Asa, Ozgur Mete
Jun 21, 2001·Brain Pathology·R N Clayton, W E Farrell

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