Intraseptal infusion of the cholinergic agonist carbachol impairs delayed-non-match-to-sample radial arm maze performance in the rat

Hippocampus
Jamie G BunceJames J Chrobak

Abstract

The medial septal nucleus regulates the physiology and emergent functions (e.g., memory formation) of the hippocampal formation. This nucleus is particularly rich in cholinergic receptors and is a putative target for the development of cholinomimetic cognitive enhancing drugs. A large number of studies have demonstrated that direct intraseptal drug infusions can produce amnestic or promnestic effects. While a few studies have examined the effects of direct intraseptal infusion of cholinomimetics on spatial memory performance (with drug "on-board" at the time of testing), the effects of post-acquisition infusions have not been assessed. We hypothesized that post-acquisition intraseptal infusion of cholinomimetics, by promoting hippocampal theta and suppressing the occurrence of hippocampal sharp waves, may disrupt the long-term retention and consolidation of memory. The present study examined the effects of intraseptal infusion of the cholinergic agonist carbachol in a delayed-non-match-to-sample radial maze task. Treatments were administered immediately following (within 1 min) the sample session with a retention session 2 h later. Carbachol infusions (12.5-125 ng in 0.5 microl) produced a linear dose-dependent decrease in corr...Continue Reading

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Citations

Jan 10, 2012·Behavioural Brain Research·Mohammad Reza ZarrindastAmeneh Rezayof
Nov 27, 2010·Behavioural Brain Research·Serena DeianaGernot Riedel
Jul 21, 2009·Neurobiology of Learning and Memory·Michael E Hasselmo
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Apr 10, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yiyao ZhangGyörgy Buzsáki

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