PMID: 9654339Jul 8, 1998Paper

Intraseptal infusions of a low dose of AP5, a NMDA receptor antagonist, improves memory in an object recognition task in rats

Neuroscience Letters
C Puma, J C Bizot

Abstract

The present study describes the effects of intraseptal microinjections of 2 nmol of AP5 upon memory of rats subjected to a two trial object recognition task. This task allows us to detect either a disruption or an improvement of memory according to the duration of the interval between the sample trial (T1) and the choice trial (T2). AP5 injected before T1 did not disrupt memory in a schedule able to detect an amnesia. In a schedule able to detect an improvement of memory, AP5 injected either 10 min before or just after T1, or 10 min before T2, improved retention. These results suggest that microinjection of a low dose of AP5 in the septum improves the acquisition, the consolidation and the restitution of the information in a working memory task.

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Nov 1, 1991·Behavioral and Neural Biology·M M'HarziJ Delacour
Jan 1, 1989·Experimental Brain Research·C MondadoriG E Fagg
Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
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Citations

Nov 24, 1999·Brain Research. Brain Research Reviews·T C Foster
Mar 20, 2003·Behavioural Brain Research·Gernot RiedelJacques Micheau
Jul 28, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C PumaJ C Bizot
Aug 19, 2014·Journal of Physiology, Paris·Magalí C CercatoDiana A Jerusalinsky
Jan 19, 2016·Pharmacology, Biochemistry, and Behavior·Fatemeh KhakpaiMohammad-Reza Zarrindast
Jun 7, 2005·Experimental Gerontology·Maria Noêmia M de LimaNadja Schröder
Oct 25, 2016·Neuropharmacology·Lorène PenazziLidia Bakota
Mar 21, 2007·Neurobiology of Learning and Memory·Arethuza DornellesNadja Schröder
May 18, 2016·Cell and Tissue Research·Jonathan BertramOliver von Bohlen Und Halbach

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