Intrasession and Between-Visit Variability of Retinal Vessel Density Values Measured with OCT Angiography in Diabetic Patients

Scientific Reports
Cecília CzakóIllés Kovács

Abstract

In clinical practice the measurement error of an instrument has special importance in analyzing and interpreting data, and acknowledging limitations. The purpose of this study was to evaluate intrasession and between-visit reproducibility of OCT angiography measurements in diabetic patients. A total of 54 eyes of 27 diabetic patients underwent OCT angiography imaging. Foveal avascular zone (FAZ) area and superficial retinal vessel density (VD) at 3 mm were calculated using the AngioAnalytics software. Three consecutive images were acquired at first visit and one image 1 month later. Intrasession and between-visit reproducibility of parameters were characterized by intraclass correlation coefficient (ICC), coefficient of variation (CV), and coefficient of repeatability (CR) values. We measured excellent (>0.90) ICC values both in intrasession and between-visit comparisons. CV was higher for the FAZ area compared to VD both in intrasession (7.79% vs. 2.87%) and in between-visit (12.33% vs. 2.95%) comparisons. Between-visit CR value for VD was 4.53% (95% CI: 3.72-5.79%). These data suggest that OCT angiography shows excellent repeatability in diabetic patients, indicating that this non-invasive technology might be suitable for lon...Continue Reading

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Citations

Jan 18, 2020·Ocular Immunology and Inflammation·Anna DastiridouSofia Androudi
Jun 7, 2020·Journal of Clinical Medicine·Jacqueline ChuaLeopold Schmetterer
Nov 12, 2019·International Journal of Retina and Vitreous·Cecília CzakóIllés Kovács
Sep 15, 2020·Therapeutic Advances in Ophthalmology·Khalil Ghasemi FalavarjaniMahsa Sardarinia
May 6, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Emily S LevineNadia K Waheed
Aug 22, 2020·Translational Vision Science & Technology·Cecilia CzakóIllés Kovács
Sep 6, 2020·Eye·Giuseppe QuerquesFrancesco Bandello
Jan 30, 2021·Asia-Pacific Journal of Ophthalmology·Enrico BorrelliFrancesco Bandello
Apr 14, 2021·Korean Journal of Ophthalmology : KJO·Yong Min LeeYoung Hoon Lee
Oct 29, 2021·Indian Journal of Ophthalmology·Enrico BorrelliFrancesco Bandello

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Methods Mentioned

BETA
imaging technique

Software Mentioned

SSADA (
SPSS
AngioAnalytics
OptoVue system
AngioVue
AngioFlow

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