Intraspecific variation in estrogen receptor alpha and the expression of male sociosexual behavior in two populations of prairie voles

Brain Research
Bruce S CushingGloria E Hoffman

Abstract

Estrogen (E) regulates a variety of male sociosexual behaviors. We hypothesize that there is a relationship between the distribution of estrogen receptor alpha (ERalpha) and the degree of male social behavior. To test this hypothesis, ERalpha immunoreactivity (IR) was compared in prairie voles (Microtus ochrogaster) from Illinois (IL), which are highly social, and Kansas (KN), which are less social. The expression of androgen receptors (AR) in males also was compared between populations. The expression of ERalpha and AR were compared in brains from KN and IL males and females using immunocytochemistry (ICC). There were significant intrapopulational differences, with males expressing less ERalpha-IR than females in the medial preoptic area, ventromedial nucleus, ventrolateral portion of the hypothalamus, and bed nucleus of the stria terminalis (BST). IL males also displayed less ERalpha-IR in the medial amygdala (MeA) than IL females. While IL males expressed significantly less ERalpha-IR in the BST and MeA than KN males, there was no difference in AR-IR. Differences in the pattern of ERalpha-IR between KN and IL males were behaviorally relevant, as low levels of testosterone (T) were more effective in restoring sexual activity ...Continue Reading

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Citations

Nov 26, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ruiyong WuChengjun Yu
Feb 9, 2012·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Fengqin HeXia Zhang
Apr 10, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Carsten Schradin
Jul 28, 2013·BMC Evolutionary Biology·David N FisherTom A R Price
Jan 13, 2012·PloS One·Lisa A McGrawJames W Thomas
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bruce S CushingEros Papademetriou
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Brent M HortonDonna L Maney
Oct 1, 2015·Developmental Psychobiology·Stephanie D PloskonkaBruce S Cushing
Jan 16, 2013·Brain Research·Brittany WilliamsPrincy S Quadros-Mennella
Dec 17, 2009·Trends in Neurosciences·Lisa A McGraw, Larry J Young
Jul 30, 2015·Hormones and Behavior·Adam N PerryBruce S Cushing
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Jul 15, 2017·Frontiers in Neuroendocrinology·Donna L Maney
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