Intrasphincteric autologous myoblast injections with electrical stimulation for stress urinary incontinence

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Mija Blaganje, Adolf Lukanović

Abstract

To assess the feasibility and safety of ultrasound-guided autologous myoblast injections into the external urethral sphincter followed by electrical stimulation (ES) as a possible 2-step treatment for stress urinary incontinence (SUI). Autologous myoblasts isolated from a biceps muscle sample were injected under transurethral ultrasound guidance into the external urethral sphincter of 38 female patients. The patients also underwent ES postoperatively to enhance cell integration. Treatment feasibility, as well as possible intraoperative and postoperative complications, was assessed 6weeks after the injections. Additionally, the effects of the myoblast injections followed by an ES cycle were compared to those of a preoperative ES cycle undergone by the same patients. No serious adverse events or complications were noted and the procedure was well tolerated. Compared with the objective and subjective measurements collected after the preoperative ES cycle, the corresponding measurements obtained 6weeks postoperatively, after the completion of a second ES cycle, indicated considerable improvement. The results to the stress test were negative for 29 (78.4%) of the patients, 5 (13.5%) considered their SUI cured, and 29 (78.4%) reporte...Continue Reading

References

Feb 26, 2003·International Urogynecology Journal and Pelvic Floor Dysfunction·J Y LeeM B Chancellor
Aug 22, 2006·Neuromuscular Disorders : NMD·Manaf BouchentoufJacques P Tremblay
Dec 28, 2006·American Journal of Physiology. Renal Physiology·Rachelle L PrantilDavid A Vorp
Mar 22, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Yumi KawaharaLouis Yuge
Jul 5, 2007·Abdominal Imaging·Katarzyna J Macura, Rene R Genadry
Aug 9, 2007·European Urology·Michael MitterbergerHannes Strasser
Jan 22, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·L K CarrM B Chancellor
Apr 27, 2010·Neurourology and Urodynamics·Dmitriy Nikolavsky, Michael B Chancellor
Nov 30, 2010·Current Urology Reports·Andrea Staack, Larissa V Rodríguez
Jul 2, 2011·Current Urology Reports·W Stuart ReynoldsDavid F Penson

❮ Previous
Next ❯

Citations

Oct 1, 2013·Archives of Gynecology and Obstetrics·M Aref-AdibW Yoong
Nov 13, 2015·Expert Opinion on Biological Therapy·Marta PokrywczynskaTomasz Drewa
Nov 8, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Maryam HajiabbasFarzaneh Sharifiaghdas
Dec 25, 2012·The Journal of Urology·Lesley K CarrMichael B Chancellor
Apr 12, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Farzaneh SharifiaghdasNeda Jaroughi
Dec 3, 2014·Advanced Drug Delivery Reviews·Lukman HakimFrank Van der Aa
Mar 4, 2014·The Journal of Urology·Kenneth M PetersMichael B Chancellor
Oct 25, 2016·The Journal of Urology·J Koudy WilliamsKarl-Erik Andersson
Oct 8, 2014·Cell Transplantation·Chaitanya GopinathJean Jacques Wyndaele
Apr 21, 2017·Annals of Surgery·Olivier BoyerUNKNOWN the Study Group of Myoblast Therapy for Faecal Incontinence
Dec 17, 2014·Current Obstetrics and Gynecology Reports·Isuzu Meyer, Holly E Richter
Nov 19, 2014·Neuropathology and Applied Neurobiology·E NegroniC Trollet
Nov 24, 2019·Stem Cell Reviews and Reports·Jung Hyun ShinMyung-Soo Choo
May 10, 2017·Journal of Tissue Engineering and Regenerative Medicine·Andrey VinarovDenis Butnaru
Jan 25, 2020·Nature Reviews. Urology·Christopher J HillaryChristopher R Chapple
May 6, 2020·World Journal of Clinical Cases·Juan ChengYa-Li Miao
May 29, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Hadar Klapper-GoldsteinAdi Y Weintraub
Aug 7, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Mija Blaganje, Adolf Lukanović

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.