Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts' Recommendations: Choosing Optimal Monitoring Tools

Stem Cells International
Magdalena Kuzma-KozakiewiczAnna Sarnowska

Abstract

Stem cells (SCs) may constitute a perspective alternative to pharmacological treatment in neurodegenerative diseases. Although the safety of SC transplantation has been widely shown, their clinical efficiency in amyotrophic lateral sclerosis (ALS) is still to be proved. It is not only due to a limited number of studies, small treatment groups, and fast but nonlinear disease progression but also due to lack of objective methods able to show subtle clinical changes. Preliminary guidelines for cell therapy have recently been proposed by a group of ALS experts. They combine clinical, neurophysiological, and functional assessment together with monitoring of the cytokine level. Here, we describe a pilot study on transplantation of autologous adipose-derived regenerative cells (ADRC) into the spinal cord of the patients with ALS and monitoring of the results in accordance with the current recommendations. To show early and/or subtle changes within the muscles of interest, a wide range of clinical and functional tests were used and compared in order to choose the most sensitive and optimal set. Additionally, an analysis of transplanted ADRC was provided to develop standards ensuring the derivation and verification of adequate quality o...Continue Reading

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References

Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Jul 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·C Collin, D Wade
Jun 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·A HellerE Ward
May 29, 1982·British Medical Journal·R J ButlandD M Geddes
Jan 7, 1998·Journal of the Neurological Sciences·J M Cedarbaum, N Stambler
May 5, 2000·The Cochrane Database of Systematic Reviews·R G MillerD H Moore
Oct 26, 2001·Journal of the Neurological Sciences·V E DroryA D Korczyn
Jun 22, 2002·The Cochrane Database of Systematic Reviews·R G MillerD H Moore
Jul 1, 2006·Neurological Research·Letizia MazziniFranca Fagioli
Oct 10, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Clarissa RamirezHelga Cristina Almeida Da Silva
Nov 26, 2009·Clinical Neurology and Neurosurgery·Markus KraemerPeter Berlit
Mar 20, 2010·Archives of Physical Medicine and Rehabilitation·Yiqin MongShamay S Ng
Mar 15, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christoph NeuwirthMarkus Weber
Aug 3, 2011·Journal of Neurology·Dorothée LuléAlbert C Ludolph
Sep 15, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies· Markus Weber
Sep 29, 2011·Muscle & Nerve·Sanjeev D NandedkarErik V Stålberg
Feb 11, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Werner A BoekesteinJohannes P van Dijk
Feb 18, 2012·The Cochrane Database of Systematic Reviews·Nigel L AshworthDan Deforge
Dec 5, 2012·Neuromuscular Disorders : NMD·Alon Abraham, Vivian E Drory
Dec 30, 2014·Annals of Clinical and Translational Neurology·Tezeta TadesseJonathan D Glass
Jun 16, 2015·The Journal of Clinical Investigation·Matthew J CrispTimothy M Miller
Jun 20, 2015·Plastic and Reconstructive Surgery. Global Open·Natalia Ewa Krześniak, Bartłomiej H Noszczyk
Feb 19, 2016·Neurology·Nimish J Thakore, Erik P Pioro
Jun 17, 2016·Neurology. Neuroimmunology and Neuroinflammation·Ching-Hua LuAndrea Malaspina
Sep 8, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jeremy M Shefner
Sep 22, 2016·Stem Cells International·Wioletta LechKrystyna Domanska-Janik
Nov 5, 2016·Cytotherapy·Nazem AtassiUNKNOWN attendees of the International Workshop on Progress in Stem Cells Research for ALS/MND
Jan 4, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christoph NeuwirthMarkus Weber

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Citations

Apr 29, 2020·Biotechnology Letters·Hamid Ahmadian-MoghadamMohammad-Reza Zarrindast
Nov 25, 2020·Neural Regeneration Research·Natalia E KrzesniakBartłomiej H Noszczyk
Apr 3, 2021·Npj Regenerative Medicine·Cynthia Morata-TarifaRosario Sanchez-Pernaute
Sep 10, 2021·Cell Transplantation·Tetsuji Sekiya, Matthew C Holley

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Methods Mentioned

BETA
Profiler
sedation

Clinical Trials Mentioned

NCT03296501

Software Mentioned

Zen
GraphPad Prism
MUNIX
MicroFET
EvolutionCapt
ACSA

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