Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model.

Scientific Reports
Hyung Woo ParkYoung Bin Choy

Abstract

Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In this study, we hypothesised that continuous, intrastriatal administration of a low dose of Coenzyme Q10 could effectively prevent dopaminergic neuron degeneration. To this end, a Parkinson's disease rat model induced by 6-hydroxydopamine was established, and the treatment was applied a week before the full establishment of this disease model. Behavioural tests showed a dramatically decreased number of asymmetric rotations in the intrastriatal Coenzyme Q10 group compared with the no treatment group. Rats with intrastriatal Coenzyme Q10 exposure also exhibited a larger number of dopaminergic neurons, higher expression of neurogenetic and angiogenetic factors, and less inflammation, and the effects were more prominent than those of orally administered Coenzyme Q10, although the dose of intrastriatal Coenzyme Q10 was 17,000-times lower than that of orally-administered Coenzyme Q10. Therefore, continuous, intrastriatal...Continue Reading

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Citations

Oct 2, 2020·International Journal of Molecular Sciences·Kyung Hee LeeBae Hwan Lee
Jan 6, 2021·Pharmaceutics·Pavan S UpadhyayulaJeffrey N Bruce
Dec 10, 2020·International Journal of Molecular Sciences·Haider ManzarM Francesca Cordeiro
Jun 30, 2021·Ecotoxicology and Environmental Safety·Yuan LiuXiangchen Li
Aug 7, 2021·Metabolic Brain Disease·Elham GhasemlooSeyyed Saeid Mousavi
Aug 17, 2021·Oxidative Medicine and Cellular Longevity·Musbau Adewumi AkanjiOluyomi Stephen Adeyemi

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