Intrastriatal adrenal medulla grafts in rats. Long-term survival and behavioral effects

Journal of Neurosurgery
W J FreedE Krauthamer

Abstract

Rats with rotational behavior consequent to unilateral lesions of the substantia nigra have been proposed for an experimental model of Parkinson's disease. Adrenal medulla or embryonic substantia nigra grafts in the lateral ventricle of these animals reduce this rotational behavior. For application to primate and human subjects, it may be necessary to implant tissue directly into the parenchyma of the corpus striatum rather than into the ventricle in order to achieve a sufficient distribution of the grafted tissues and increase the efficacy of the grafts. In the present study, the properties of intraparenchymal adrenal medulla grafts were investigated. Grafts were obtained from both young (4 to 5 weeks old) and aging (22 to 24 months old) donor rats. Much of the implanted tissue did not survive, although 200 chromaffin cells per recipient rat were found to have survived for at least 6 months. All of the surviving cells developed process-like cytoplasmic extensions, although these processes did not appear to have reinnervated host brain tissue. Grafts from both young and aging donor rats prevented a slight deterioration in the performance of a sensory neglect test that was observed in a control group that received grafts of scia...Continue Reading

References

Dec 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L A Sternberger
Aug 1, 1979·The Journal of Cell Biology·G F Gauthier
Mar 15, 1979·Documenta Ophthalmologica. Advances in Ophthalmology·C La Lau
Aug 1, 1979·Experimental Eye Research·A Pellegrino de Iraldi, J P Corazza
Mar 1, 1979·Pharmacology, Biochemistry, and Behavior·M F Walsh, E K Silbergeld
Mar 1, 1985·Brain : a Journal of Neurology·D V RajM S Devanandan
Mar 1, 1974·Journal of Comparative and Physiological Psychology·J F Marshall, P Teitelbaum
Oct 1, 1980·Journal of Neuroscience Methods·J C De la Torre
Jun 13, 1983·Brain Research·W J FreedR J Wyatt
Aug 1, 1956·The American Journal of Medicine·J SEGALC HUFNAGEL
Sep 1, 1958·Journal of Clinical Pathology·D J ASHLEY
Sep 1, 1956·Proceedings of the National Academy of Sciences of the United States of America·I E Segal
Feb 1, 1946·The Anatomical Record·M ABERCROMBIE

❮ Previous
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Citations

Mar 1, 1991·Journal of Cellular Biochemistry·W J FreedE I Ginns
May 1, 1990·Brain Research. Brain Research Reviews·A Fine
Nov 1, 1995·Neurobiology of Aging·J L Mendoza-RamírezR Drucker-Colín
Sep 1, 1994·Progress in Neurobiology·J P Herman, N D Abrous
Mar 30, 1992·Neuroscience Letters·S Jiao, J A Wolff
Jan 1, 1989·Brain Research Bulletin·A B NormanP R Sanberg
Jan 1, 1993·Brain Research Bulletin·P R SanbergA B Norman
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K UnsickerH D Hofmann
Aug 23, 2005·Brain Research. Brain Research Reviews·Emilio Fernandez-EspejoSusana Ramiro
Jun 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·O Lindvall
Nov 6, 2012·Life Sciences·Mónica Ambriz-TututiRené Drucker-Colín
Oct 1, 1994·Microscopy Research and Technique·J T Hansen, D M Gash
Jan 1, 1989·Acta Neurologica Scandinavica. Supplementum·O Lindvall, A Björklund
Jan 1, 1993·Reviews in the Neurosciences·C GagnonT Di Paolo
Apr 1, 1993·Reviews in the Neurosciences·R Barker, S Dunnett
Jan 1, 1987·Annals of the New York Academy of Sciences·W J FreedS S Schwarz
Jul 15, 1988·Science·W J Freed

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