PMID: 8939469Oct 25, 1996Paper

Intrastriatal injection of the metabotropic glutamate receptor antagonist MCPG attenuates acute amphetamine-stimulated neuropeptide mRNA expression in rat striatum

Neuroscience Letters
J Q Wang, J F McGinty

Abstract

In chronically cannulated rats, microinjection of a competitive metabotropic glutamate receptor (mGluR) antagonist, (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), into the dorsal striatum at doses of 0.4, 2 and 10 micrograms/1 microliter did not affect basal levels of preprodynorphin, substance P and preproenkephalin mRNAs in the dorsal striatum as revealed by quantitative in situ hybridization. However, intrastriatal MCPG (0.08, 0.4 and 2 micrograms/1 microliter) dose-dependently attenuated increases in the three mRNA expression induced by acute amphetamine injection (2 mg/kg, i.p.). MCPG had no significant effect on spontaneous, and amphetamine-stimulated, behavioral activities. These data indicate that activation of MCPG-sensitive mGluRs is necessary for upregulation of striatal neuropeptide mRNA expression in response to amphetamine exposure. However, the mGluR activity is not implicated in maintaining basal levels of the peptide gene expression in the striatum.

Citations

May 16, 1998·Brain Research. Molecular Brain Research·J Q Wang, J F McGinty
Dec 14, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Wenxia ZhouJacqueline F McGinty
Jun 1, 2007·Pharmacology, Biochemistry, and Behavior·Marcela Morales-MuliaMilagros Méndez
Apr 1, 1999·Addiction Biology·J Q Wang, J F McGinty
Jul 23, 1999·Annals of the New York Academy of Sciences·J F McGinty

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