PMID: 8943073Nov 26, 1996Paper

Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal gamma-aminobutyric acid transmission in the conscious rat

Proceedings of the National Academy of Sciences of the United States of America
W SommerK Fuxe

Abstract

Antisense c-fos oligonucleotides injected into the neostriatum of conscious rats selectively inhibited c-fos expression associated with compensatory increases in striatal c-fos mRNA levels and also with increased expression of junB and NGFI-A mRNA, probably as a result of regulatory phenomena. Dual probe in vivo microdialysis was used to investigate gamma-aminobutyric acid (GABA) release in the substantia nigra and the globus pallidus, which represent the terminal sites of the dopamine D1 receptor regulated striatonigral and the dopamine D2 receptor regulated striatopallidal GABA pathways, respectively. Intrastriatal infusion of the c-fos antisense oligonucleotide profoundly decreased dialysate GABA levels in the ipsilateral substantia nigra within 60 min but did not influence the dialysate GABA levels in the globus pallidus compared with the sham and control oligonucleotide treated groups. The site of action of the antisense oligonucleotides was mainly restricted to striatal neurons as shown by the distribution of locally injected fluoresceine isothiocyanate and radiolabeled oligonucleotides. The findings demonstrate a facilitatory role for c-fos mediated gene regulation in striatonigral GABA transmission and strengthen the ev...Continue Reading

References

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Citations

Jul 9, 1999·The Journal of Comparative Neurology·M O Hebb, H A Robertson
Jul 24, 1998·Brain Research. Molecular Brain Research·B J ChiassonH A Robertson
Oct 7, 1998·Epilepsy Research·C DeransartA Depaulis
Dec 24, 1998·Nuclear Medicine and Biology·W T O'Connor
Nov 22, 2014·Frontiers in Integrative Neuroscience·Wolfgang H SommerAnita C Hansson
Mar 28, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K BjörkW H Sommer
Oct 9, 2019·Translational Psychiatry·Markus HeiligWolfgang H Sommer
Feb 15, 2021·Neuropharmacology·Miriam WandresChristoph Körber

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