PMID: 6402406Mar 1, 1983Paper

Intratesticular transplants of islet xenografts (rat to mouse)

Diabetes
B BobzienJ M Davie

Abstract

Freshly isolated rat islets were transplanted into the testis of diabetic mice. The intratesticular islet xenografts produced normoglycemia in the diabetic recipients. The survival time of the intratesticular xenografts was significantly longer than intrasplenic, intrahepatic, and renal subcapsular sites of transplantation of xenografts of freshly isolated rat islets. Three of the recipients with intratesticular islet grafts were still normoglycemic at 60 days after transplantation, and orchidectomy resulted in a return to the diabetic state. The findings indicate that the testis provided a more privileged immunologic site than either the spleen, liver, or kidney and the lower temperature of the testis apparently did not affect the function of the islet grafts since the recipients became normoglycemic.

Citations

Jun 1, 1991·Diabetologia·D PipeleersG Klöppel
Nov 1, 1988·Journal of Reproductive Immunology·P PöllänenJ Uksila
Aug 1, 1990·Journal of Reproductive Immunology·S Maddocks, B P Setchell
Jul 1, 1991·Immunology Letters·D W Gray
Jun 1, 1997·Transplantation Proceedings·D A CoddingtonJ R Wright
Nov 20, 1997·Transplantation Proceedings·M A BakrM A Ghoneim
Apr 9, 1998·Transplantation Proceedings·A RefaieM A Ghoneim
Oct 19, 2002·Journal of Reproductive Immunology·Mark P Hedger
Mar 17, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·S A WhiteM L Nicholson
Oct 10, 2013·Clinical & Developmental Immunology·Andrew R PepperA M James Shapiro
Mar 26, 2014·Gastroenterology·Majid MojibianTimothy J Kieffer
Jul 23, 1999·Annals of the New York Academy of Sciences·G R RayatG S Korbutt
Jun 22, 2005·Treatments in Endocrinology·Daniel M RidgwayRachel M Kimber
Apr 1, 1984·World Journal of Surgery·P E Lacy
Apr 1, 1984·World Journal of Surgery·D W Scharp
Jun 1, 1986·World Journal of Surgery·D W Gray, P J Morris
Nov 8, 2003·Immunological Investigations·Jannette M DufourDwaine F Emerich
Feb 15, 2000·International Reviews of Immunology·D Bellgrau, R C Duke
Jun 2, 2009·The Journal of Surgical Research·Maciej T JuszczakMartin Press
Jan 8, 2004·Xenotransplantation·Jannette M DufourGregory S Korbutt
Sep 16, 2006·Immunological Reviews·Monika Fijak, Andreas Meinhardt
Nov 11, 2008·The British Journal of Surgery·S MeraniA M J Shapiro
Jul 21, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Q GaoD P Yin
Sep 4, 2013·Diabetes/metabolism Research and Reviews·Naoaki SakataMichiaki Unno
Mar 1, 1992·Diabetes Research and Clinical Practice·W J TzeS S Cheung
Jun 1, 1993·Gastroenterology Clinics of North America
Jan 11, 2005·World Journal of Gastroenterology : WJG·Yun-Fu CuiMichael D Menger
Aug 26, 2014·Frontiers in Bioengineering and Biotechnology·Genaro Alberto Paredes JuárezPaul de Vos
May 8, 2018·International Journal of Molecular Sciences·Naoaki SakataShohta Kodama
Nov 1, 1994·Cell Transplantation·A Ar'RajabJ T Sentementes
Oct 19, 1995·Nature·D BellgrauR C Duke
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isam W NasrZhenhua Dai
Aug 13, 2003·Cell Transplantation·Dwaine F EmerichCraig R Halberstadt
Apr 3, 2019·Advanced Science·Zhenzhen WangLei Dong
Feb 16, 2016·Cell Transplantation·Hajime MatsushimaSusumu Eguchi
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Xin ZhaoHuaqiang Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.