PMID: 9552783Apr 29, 1998Paper

Intrathecal addition of morphine to bupivacaine is not the cause of postoperative nausea and vomiting

Regional Anesthesia and Pain Medicine
E W WeberR Dirksen

Abstract

Postoperative nausea and vomiting after anesthesia is an distressing side effect. This study was undertaken to determine to what extent spinal opioids contribute to postoperative nausea and vomiting (PONV) and secondly to how effectively metoclopramide can reduce the incidence of PONV after intrathecal administration of morphine. Patients were allocated to three groups all undergoing major joint surgery of the lower limb. In group 1 (n = 200), intrathecal anesthesia was assessed by administration of 20 mg bupivacaine and 0.2 mg morphine. In Group 2 (n = 100) intrathecal anesthesia was assessed in the same way and in addition, 20 mg metoclopramide intramuscular during maintenance of anesthesia and a second dose of 20 mg metoclopramide was administered intramuscular after arrival at the recovery room. Finally, in group 3 (n = 100), intrathecal anesthesia was assessed after administration of 20 mg bupivacaine. The maximum PONV percentages were 41.1%, 32.7%, and 37% in groups 1, 2, and 3, respectively. The consumption of antiemetics was similar in all groups. The number of patients who needed one or more additional antiemetics during the first 24 hours after surgery was 112 (56.6%), 57 (58%), and 60 (60%) in groups 1, 2, and 3, res...Continue Reading

Citations

Oct 8, 2003·Best Practice & Research. Clinical Anaesthesiology·Helmut R Gerber
Oct 30, 2016·Revista brasileira de anestesiologia·Eduardo Toshiyuki MoroJulia Morais Barbieri
Oct 30, 2016·Brazilian Journal of Anesthesiology·Eduardo Toshiyuki MoroJulia Morais Barbieri
Nov 25, 2003·Anesthesia and Analgesia·P M MurphyJ G Laffey
Jan 29, 2003·Anesthesiology·Alain BorgeatCarlo A Schenker
Oct 26, 2000·European Journal of Anaesthesiology·R SlappendelR Dirksen
Dec 13, 2005·Anesthesia and Analgesia·James P RathmellBushra Nauman
Apr 9, 1999·Anesthesia and Analgesia·R SlappendelJ van Limbeek

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