PMID: 9821998Nov 20, 1998Paper

Intrathecal adenosine administration: a phase 1 clinical safety study in healthy volunteers, with additional evaluation of its influence on sensory thresholds and experimental pain

Anesthesiology
K RaneA Sollevi

Abstract

Several animal studies show antinociceptive effects of intrathecally administered adenosine and its analogs. However, there is no clinical experience regarding the effects of intrathecal adenosine in humans. The side effects and analgesic effects of intrathecal adenosine (500-2,000 microg) on experimental pain were studied in 12 healthy volunteers. Before and after adenosine was given, the authors evaluated the cold pain rating of the foot (submersion in ice water for 1 min), the forearm ischemic pain rating during a 30-min tourniquet test, and the thermal and tactile pain thresholds on healthy and inflamed skin after application of mustard oil (4 min) to the calf. The areas of secondary allodynia surrounding the inflammation were also determined. The cerebrospinal fluid level of adenosine was determined before and after injection. Intrathecal adenosine caused a 1,000- to 2,000-fold elevation of the cerebrospinal fluid concentration. One volunteer experienced transient (30 min) lumbar pain after injection at a dose of 2,000 microg. There were no other complications in any other volunteers. Adenosine reduced, in a non-dose-dependent manner, the areas of secondary allodynia after skin inflammation (brush, P < 0.06; and von Frey h...Continue Reading

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Citations

Oct 5, 2006·Current Opinion in Anaesthesiology·S P Cohen, S Abdi
Sep 1, 2014·Journal of Clinical Monitoring and Computing·M CzernickiN Vadivelu
Dec 22, 1999·Anesthesiology·P M Dougherty, P S Staats
Sep 15, 1999·Anesthesiology·A ChiariJ C Eisenach
Mar 2, 2006·European Journal of Anaesthesiology·M SharmaR Chawla
Oct 4, 2006·Current Opinion in Anaesthesiology·S A SchugH M Cardwell
Sep 27, 2006·Neuroreport·Thomas J MartinSteven R Childers
Jul 25, 2007·Anesthesia and Analgesia·Tong J Gan, Ashraf S Habib
Apr 29, 2010·Current Pain and Headache Reports·Erin F Lawson, Mark S Wallace
Oct 3, 2002·Anesthesiology·James C EisenachDavid D Hood
Aug 12, 2000·Acta Anaesthesiologica Scandinavica·K RaneM Segerdahl
Jul 21, 2005·Journal of Anesthesia·Masakazu HayashidaAtsuo Fukunaga
Apr 18, 2003·Acta Anaesthesiologica Scandinavica·K RaneM Segerdahl
May 30, 2002·Progress in Neurobiology·Mark J Millan
Nov 10, 2004·Brain Research·Gabriella KekesiGyongyi Horvath
Feb 21, 2006·Brain Research Reviews·Gyongyi Horvath, Gabriella Kekesi

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