Intrathecal administration of CGRP in the rat attenuates a facilitation of the tail flick reflex induced by either substance P or noxious cutaneous stimulation.

Neuroscience Letters
R A Cridland, J L Henry

Abstract

Intrathecal (i.t.) administration of substance P in the awake rat decreases reaction time (RT) in the tail flick test. In the anaesthetized rat, noxious thermal stimulation of the tail (by immersion of tip in water at 55 degrees C) also decreases RT; this effect is blocked by a substance P antagonist. The present study examines the effects of calcitonin gene-related peptide (CGRP) on the decrease in RT produced in these two paradigms. Pretreatment with CGRP (3.25 nmol, i.t.) attenuated and abolished the decreases in RT produced by substance P (3.25 nmol, i.t.) and by noxious cutaneous stimulation, respectively. These results indicate an interaction of CGRP and substance P in the regulation of the tail flick reflex.

References

Sep 24, 1985·European Journal of Pharmacology·P Le GrevesT Hökfelt
Apr 1, 1988·Brain Research Bulletin·R A Cridland, J L Henry
Oct 1, 1984·Brain Research Bulletin·K Yashpal, J L Henry

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Citations

Jan 1, 1992·Pharmacology & Therapeutics·D R Poyner
May 1, 2013·Plastic and Reconstructive Surgery·Harvey ChimBahman Guyuron
Nov 5, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Nadeem KhanAmteshwar Singh Jaggi
Dec 22, 1999·Anesthesiology·P M Dougherty, P S Staats
Aug 25, 2006·Annals of Plastic Surgery·Chunhui SongWilliam C Lineaweaver

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