PMID: 9535120Apr 16, 1998Paper

Intrathecal administration of the adenosine A1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain

Neuroscience Letters
K F SjölundZ Wiesenfeld-Hallin

Abstract

Effects of intrathecally (i.t.) administered R-phenylisopropyl adenosine (R-PIA), an adenosine A1 receptor agonist, on presumed pain behaviour were assessed in a rat model of chronic central pain. Spinal cord injury was induced photochemically via laser irradiation of the spinal cord after intravenous injection of erythrosin B in rats. The chronic allodynia-like behaviour that developed in some animals was studied. R-PIA (3 and 10 nmol), injected i.t. reduced the mechanical and cold allodynia-like symptoms as tested with von Frey filaments and ethyl-chloride spray, respectively. No side effects were observed. The effect of R-PIA was significant for up to 5 h and was reversed by theophylline, an adenosine receptor antagonist.

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Citations

Jul 21, 2005·Journal of Anesthesia·Masakazu HayashidaAtsuo Fukunaga
May 15, 2002·European Journal of Pharmacology·Annie MauborgneSylvie Bourgoin
Feb 13, 1999·Progress in Neurobiology·M J Millan
Nov 11, 1999·Drug Discovery Today·S M Kaiser, R J Quinn
Aug 12, 2000·Acta Anaesthesiologica Scandinavica·K RaneM Segerdahl
Jun 1, 2008·Gut and Liver·Chong-Il SohnG F Gebhart
Sep 13, 2011·Progress in Neurobiology·Geoffrey BurnstockPeter Illes
Apr 18, 2003·Acta Anaesthesiologica Scandinavica·K RaneM Segerdahl
Mar 2, 2005·Pharmacology & Therapeutics·Kui XuMichael Schwarzschild
Jan 26, 2016·British Journal of Pharmacology·K JanesD Salvemini
Mar 11, 1999·Anesthesia and Analgesia·K F SjölundA Sollevi
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Xinhui LiJames C Eisenach
Oct 4, 2006·Current Opinion in Anaesthesiology·S A SchugH M Cardwell
Sep 15, 1999·Anesthesiology·A ChiariJ C Eisenach

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