Intrathecal anti-alphaB-crystallin IgG antibody responses: potential inflammatory markers in Guillain-Barré syndrome.

Journal of Neurology
Julia WanschitzThomas Berger

Abstract

alphaB-crystallin (alphaBC), a small stress protein with cytoprotective and anti-apoptotic functions, is a potent antigen in autoimmune demyelinating diseases. To address the role of alphaBC in Guillain-Barré syndrome (GBS) we analyzed humoral responses against alphaBC in relation to clinical, electrophysiological and CSF features in GBS. Anti-alphaBC-IgG antibodies were measured in serum and cerebrospinal fluid (CSF) of patients with GBS (n = 41), infectious inflammatory neurological diseases (n = 21), multiple sclerosis (n = 42), and other, non-inflammatory neurological disorders (n = 40) by ELISA using human recombinant alphaBC. Expression of alphaBC was immunohistochemically analyzed in postmortem peripheral nerve tissue of GBS and controls without neuropathy. Serum alphaBC-IgG antibody levels did not differ between disease groups, whereas alphaBC-IgG antibodies in CSF were increased in GBS and infectious inflammatory neurological diseases. Calculation of an antigen specific alphaBC-IgG index (alphaBC-Ig-G(CSF) x total IgG(CSF))/(alphaBC-IgG(Serum) x total IgG(Serum)) revealed significantly elevated values in patients with GBS compared to other disease groups (p < 0.001). alphaBC-IgG indices exceeding a cut off value > 0.8 ...Continue Reading

References

Oct 7, 1978·Lancet·R A HughesJ M Pierce
Apr 23, 1992·The New England Journal of Medicine·A H Ropper
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R KlemenzA Aoyama
Jan 1, 1990·Annals of Neurology·A K Asbury, D R Cornblath
Jan 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T IwakiJ E Goldman
May 1, 1996·Journal of Neuroimmunology·F DeisenhammerE J Thompson
Dec 13, 1997·The Journal of Infectious Diseases·R A Hughes, J H Rees
Sep 24, 1998·Lancet·A F Hahn
Feb 24, 2001·Journal of Neurology·B CeletG Saruhan-Direskeneli
Jun 19, 2001·Archives of Neurology·P H Gordon, A J Wilbourn
Nov 14, 2002·Brain : a Journal of Neurology·Hugh J Willison, Nobuhiro Yuki
Aug 21, 2003·Lancet·A Graham Pockley
Jan 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dianna WillisJeffery L Twiss
Jun 17, 2005·Journal of the Peripheral Nervous System : JPNS·Hugh J Willison
Nov 8, 2005·Lancet·Richard A C Hughes, David R Cornblath
Aug 26, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F DeisenhammerUNKNOWN EFNS Task Force
Jun 15, 2007·Nature·Shalina S OusmanLawrence Steinman

❮ Previous
Next ❯

Citations

Apr 9, 2011·Molecular & Cellular Proteomics : MCP·Yasuhiro KatsumataMasako Hara
Dec 27, 2016·Journal of the Neurological Sciences·Claudia RinkHarald Prüss
Oct 3, 2009·Interactive Cardiovascular and Thoracic Surgery·Radostina ChernevaNedka Trifonova
Jul 16, 2010·Journal of the Peripheral Nervous System : JPNS·Harald HegenThomas Berger
May 10, 2020·Cell Stress & Chaperones·Junna Hayashi, John A Carver
Nov 27, 2020·Frontiers in Neurology·Chuxin HuangWei Lu

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.