PMID: 3755251May 1, 1986Paper

Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis

Regulatory Peptides
R J KosloF Porreca

Abstract

The role of the pituitary-adrenal axis in the inhibition of gastrointestinal transit caused by intrathecal administration of bombesin was examined. Bombesin (0.3-10 micrograms) slowed transit by this route in a dose-related manner. Either hypophysectomy or adrenalectomy prevented the inhibition of gastrointestinal transit associated with bombesin (10 micrograms, i.th.). The inhibitory gut effects of this peptide were not prevented in sham-operated rats. Intrathecal bombesin-induced inhibition of gastrointestinal transit is thus dependent upon an intact pituitary-adrenal axis.

References

Jan 27, 1986·Life Sciences·T K BanerjiA Rassoli
Nov 1, 1983·Peptides·D E Gmerek, A Cowan
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y TachéM Brown
Oct 14, 1983·European Journal of Pharmacology·D E GmerekJ L Vaught
Oct 17, 1980·European Journal of Pharmacology·J L Hylden, G L Wilcox
Dec 17, 1982·European Journal of Pharmacology·F PorrecaT F Burks
Nov 1, 1981·Journal of Pharmacological Methods·M S MillerT F Burks
Apr 28, 1980·Brain Research·Y TachéM Brown

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Citations

Jan 1, 1990·Annals of the New York Academy of Sciences·T F Burks
Oct 8, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Matthew QuinnSharon Demorrow
Jan 1, 1988·Annals of the New York Academy of Sciences·F PorrecaR J Sheldon
Nov 11, 2017·International Journal of Molecular Sciences·Anca D PetrescuSharon DeMorrow
Oct 3, 2015·Molecular Endocrinology·Matthew McMillinSharon DeMorrow

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