PMID: 9523808Apr 2, 1998Paper

Intrathecal clonidine combined with sufentanil for labor analgesia

Anesthesiology
P E GautierJ L Hody

Abstract

Intrathecal sufentanil provides rapid-onset and complete analgesia for the first stage of labor. The dose required to produce this effect can be associated with maternal respiratory depression, hypotension, nausea, or pruritus. Because clonidine potentiates the analgesic effects of opioids without increasing their side effects, the authors wanted to determine the efficacy of low doses of intrathecal clonidine (15 and 30 microg) combined with sufentanil. Ninety-eight parturient requesting labor analgesia were studied. In a combined spinal-epidural technique, patients were randomly assigned to receive one of the following intrathecal solutions: either 15 microg clonidine (n = 10); 30 microg clonidine (n = 10); 2.5 microg sufentanil (n = 13); 5 microg sufentanil (n = 13); 2.5 microg sufentanil and 15 microg clonidine (n = 13); 2.5 microg sufentanil and 30 microg clonidine (n = 13); 5 microg sufentanil and 15 microg clonidine (n = 13); or 5 microg sufentanil and 30 microg clonidine (n = 13). Visual analog scores for pain, blood pressure, heart rate, sensory levels, incidence of nausea and pruritus, and motor blockade, and maternal and cord blood concentrations of clonidine were recorded. Patients receiving 30 microg intrathecal clo...Continue Reading

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Citations

Sep 16, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A T Sia
Sep 7, 2006·Der Schmerz·C HampelC Spies
Jan 21, 2004·Current Pain and Headache Reports·George BowenAngelo Andonakakis
Dec 31, 2004·Current Pain and Headache Reports·James W Heitz, Eugene R Viscusi
Sep 16, 2000·Journal of Pain and Symptom Management·G BennettT Yaksh
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Aug 29, 2002·Anesthesia and Analgesia·Suellen M WalkerDaniel B Carr
May 25, 2004·Anesthesia and Analgesia·Adam P TuckerColin S Goodchild
Sep 24, 2004·Anesthesia and Analgesia·Stephan StrebelChristoph H Kindler
Jul 28, 2012·International Journal of Critical Illness and Injury Science·Sukhminder Jit Singh BajwaSurjit Singh Parmar
Jan 15, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·L ArnaoutA Mignon
May 8, 2014·Journal of Anaesthesiology, Clinical Pharmacology·Pooja Chopra, Vandana Talwar
Aug 18, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Carlo MissantMarc Van de Velde
Oct 4, 2006·Current Opinion in Anaesthesiology·S A SchugH M Cardwell
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Apr 14, 2015·The American Journal on Addictions·Timothy WilensIsela Catalina-Wellington
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Dec 23, 2004·Paediatric Drugs·Giorgio Capogna, Michela Camorcia
Dec 18, 1998·Anesthesiology·L C Goudas, D B Carr

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