Intrathecal clonidine decreases propofol sedation requirements during spinal anesthesia in infants

Paediatric Anaesthesia
Yatindra K BatraRajeev Subramanyam

Abstract

Propofol is a popular agent for providing procedural sedation in pediatric population during lumbar puncture and spinal anesthesia. Adjuvants like clonidine and fentanyl are administered intrathecally to prolong the duration of spinal anesthesia and to provide postoperative analgesia. We studied the propofol requirement after intrathecal administration of clonidine or fentanyl in infants undergoing lower abdominal surgeries. Sixty-five ASA I infants undergoing elective lower abdominal surgery under spinal anesthesia were assigned into four groups in this prospective randomized double-blinded study. Group B received bupivacaine based on body weight (<5 kg = 0.5 mg kg(-1); 5-10 kg = 0.4 mg kg(-1)). Group BC received 1 microg kg(-1) of clonidine with bupivacaine, group BF received 1 microg kg(-1) of fentanyl with bupivacaine, and patients in group BCF received 1 microg kg(-1) each of clonidine and fentanyl with bupivacaine. A bolus of 2-3 mg kg(-1) of propofol bolus was administered for lumbar puncture. Sedation was assessed using a six-point sedation score (0-5) and a five-point reactivity score (0-4) which was based on a behavioral score. After achieving a sedation and reactivity score of 3-4, the patients were placed lateral in...Continue Reading

References

Jan 13, 2000·Paediatric Anaesthesia·J D Tobias
Sep 30, 2000·Paediatric Anaesthesia·M Yamashita
Nov 25, 2003·Annals of Emergency Medicine·Elisabeth GuentherDouglas S Nelson
Dec 25, 2003·Anesthesia and Analgesia·Alain RochetteXavier Capdevila
Jul 4, 2006·British Journal of Anaesthesia·H HermannsM Jetzek-Zader
May 5, 2007·Current Opinion in Anaesthesiology·Andrew J Davidson
Jan 16, 2009·Paediatric Anaesthesia·Nicola DismaAndrew J Davidson

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Citations

Oct 23, 2010·Paediatric Anaesthesia·Andrew Weatherall, Rasa Venclovas
Jun 25, 2014·Paediatric Anaesthesia·Lee BlackburnBrian J Anderson
Feb 13, 2018·Current Opinion in Anaesthesiology·Nicola DismaGeorge A Chalkiadis
Apr 10, 2020·The Cochrane Database of Systematic Reviews·Olga RomantsikMatteo Bruschettini
Apr 23, 2014·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Christoph HünselerUNKNOWN Clonidine Study Group

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