Intrathecal drug delivery in the era of nanomedicine.

Advanced Drug Delivery Reviews
M J FowlerR W Sirianni

Abstract

Administration of substances directly into the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord is one approach that can circumvent the blood-brain barrier to enable drug delivery to the central nervous system (CNS). However, molecules that have been administered by intrathecal injection, which includes intraventricular, intracisternal, or lumbar locations, encounter new barriers within the subarachnoid space. These barriers include relatively high rates of turnover as CSF clears and potentially inadequate delivery to tissue or cellular targets. Nanomedicine could offer a solution. In contrast to the fate of freely administered drugs, nanomedicine systems can navigate the subarachnoid space to sustain delivery of therapeutic molecules, genes, and imaging agents within the CNS. Some evidence suggests that certain nanomedicine agents can reach the parenchyma following intrathecal administration. Here, we will address the preclinical and clinical use of intrathecal nanomedicine, including nanoparticles, microparticles, dendrimers, micelles, liposomes, polyplexes, and other colloidalal materials that function to alter the distribution of molecules in tissue. Our review forms a foundational understanding of drug de...Continue Reading

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Citations

May 22, 2020·Frontiers in Cell and Developmental Biology·Beatrice SalvatoriMariangela Morlando
Oct 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dusica MaysingerAshok Kakkar
Jan 14, 2021·Trends in Molecular Medicine·Verena I BöhmerPhilip H Elsinga
Feb 2, 2021·Frontiers in Human Neuroscience·Jennifer A ChandlerHemmings Wu
Feb 5, 2021·Advanced Drug Delivery Reviews·S G AntimisiarisS Mourtas
Dec 17, 2020·Pharmaceutics·Jessica I GriffithWilliam F Elmquist
Jan 24, 2021·Advanced Drug Delivery Reviews·Renjie LiuGregory A Hudalla
Oct 24, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yadan ZhangDongqin Quan
Mar 12, 2021·Advanced Drug Delivery Reviews·Ghazal Naseri KouzehgaraniDidier R Lefebvre
Mar 17, 2021·Acta Biomaterialia·Zhan-Shan GaoChao Wu
May 14, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shivanand PudakalakattiPratip K Bhattacharya
Jul 25, 2021·International Journal of Molecular Sciences·Frida Lind-Holm MogensenMaiken Nedergaard

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