Intrathecal hydromorphone for intractable nonmalignant pain: a retrospective study

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Stuart Du PenJon Hillyer

Abstract

Hydromorphone is often administered intrathecally for the treatment of cancer and nonmalignant chronic intractable pain. It is frequently utilized in combination with other analgesics in a multidrug intrathecal infusion; however, very little data are available documenting efficacy or safety of intrathecal hydromorphone as a solo analgesic. This study was conducted to examine pain and side effects in patients receiving intrathecal hydromorphone. A retrospective review was conducted of all patients receiving intrathecal hydromorphone monotherapy in two large pain specialty practices in the Pacific Northwest. All data collected within 30 days of the patient's 3-month, 6-month, and 12-month anniversary of implant were analyzed. Twenty-four patients with noncancer-related chronic pain were included in the study. Thirteen patients had eligible pain data at 1 month, 10 patients had pain data at 3 months and seven patients had pain data available at 12 months after initiation of intrathecal hydromorphone. Average pain scores decreased significantly (P = 0.03). Side-effect and pain-interference scores remained essentially unchanged in this small sample of patients.

References

Jan 1, 1983·Clinical Neurosurgery·B M Onofrio
Feb 1, 1996·Journal of Pain and Symptom Management·J A PaiceS Shott
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S L Du PenK Syrjala
Jun 27, 2003·Anesthesiology·Tony L YakshKeith R Hildebrand
Jun 27, 2003·Anesthesiology·Tamara Lee GradertSamuel J Hassenbusch
Nov 14, 2003·The New England Journal of Medicine·Jane C Ballantyne, Jianren Mao
Mar 5, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mary J JohansenSamuel J Hassenbusch
Apr 23, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·V C AndersonK J Burchiel
Oct 1, 2003·Neuromodulation : Journal of the International Neuromodulation Society·Fernandez JuliusClaudio A Feler

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Citations

Sep 24, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jill M MhyreLinda S Polley
Sep 1, 2006·Photomedicine and Laser Surgery
Sep 23, 2010·Indian Journal of Palliative Care·Naveen S Salins, Gregory B Crawford
May 12, 2007·Expert Review of Neurotherapeutics·Gaetan MoiseChristopher J Winfree
Aug 24, 2013·Journal of Clinical Anesthesia·Nicole C BeattyAdam K Jacob
Dec 7, 2007·Anesthesiology Clinics·Steven P Cohen, Anthony Dragovich
Dec 7, 2007·Anesthesiology Clinics·John D Markman, Annie Philip
Oct 24, 2007·Peptides·Richard J Bodnar
Feb 27, 2007·The Medical Clinics of North America·Steven P Cohen, Anthony Dragovich
Feb 27, 2007·The Medical Clinics of North America·John D Markman, Annie Philip
Oct 15, 2013·Pain Practice : the Official Journal of World Institute of Pain·Ann Ver DonckJan Van Zundert
Mar 15, 2011·Journal of Pain and Symptom Management·Greta G CummingsNeil A Hagen
Sep 20, 2016·International Journal of Obstetric Anesthesia·G C Lynde
Oct 26, 2007·Anesthesia and Analgesia·Michelle Lotto, Nicholas M Boulis
Nov 22, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Virginia L GhafoorPamela K Phelps
Mar 7, 2019·Neuromodulation : Journal of the International Neuromodulation Society·David Daewhan KimNabil Sibai
Mar 20, 2013·Environmental Management·José Pablo Prado CórdovaJan Börner
Aug 3, 2020·JAAPA : Official Journal of the American Academy of Physician Assistants·Shilpa GajarawalaMark Archambault
Oct 27, 2015·Drugs·Catherine SmythMohammed T Ansari

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