PMID: 6162012Jan 1, 1981Paper

Intrathecal IgG synthesis in multiple sclerosis: comparison between isoelectric focusing and quantitative estimation of cerebrospinal fluid IgG

Journal of Neurology
P LivreaR Leante

Abstract

Isoelectric focusing of CSF and serum IgG followed by crossed immuno isoelectric focusing and direct immunofixation as well as quantitative assay of IgG and albumin were performed in 64 clinically definite multiple sclerosis patients. Intrathecal IgG synthesis was calculated according to the CSF IgG index and de novo CNS IgGsyn. Isoelectric focusing showed abnormal IgG fractions i CSF indicating increased intrathecal synthesis of oligoclonal IgG in 99% of patients. Only 62% and 70% of multiple sclerosis patients showed values of CSF IgG indices and de novo CNS IgGsyn higher than in controls. Increased intrathecal IgG synthesis was indicated more frequently by de novo CNS IgGsyn in patients with a normal CSF IgG index than by the CSF IgG index in patients with normal de novo CNS IgGsyn. All patients with blood CSF barrier damage had increased de novo CNS IgGsyn, but only 40% had an increased CSF IgG index. Isoelectric focusing seemed to be a more sensitive method to detect an increased intrathecal oligoclonal IgG synthesis than quantitative methods. Identification of abnormal IgG fractions can be performed easily and with more reproducible results by direct immunofixation than by crossed immuno isoelectric focusing. The formula ...Continue Reading

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Citations

Nov 1, 1989·Journal of the Neurological Sciences·J H SouverijnG W Bruyn
Feb 1, 1984·Journal of Neuroimmunology·P D MehtaJ A Miller
Jan 1, 1981·Clinical Neurology and Neurosurgery·P Delmotte, H Carton
Oct 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·A J ThompsonC Feighery
Feb 17, 2009·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jan MaresPetr Kanovsky
Aug 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·M AnderssonM Grønning
Jan 26, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M AuerF Deisenhammer
Jan 1, 1985·Annals of Neurology·W W TourtellotteK Syndulko
Sep 1, 1990·Annals of Clinical Biochemistry·E J Thompson, G Keir

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