Intrathecal Immunoglobulin for treatment of adult patients with tetanus: A randomized controlled 2x2 factorial trial.

Wellcome Open Research
Huynh T LoanC Louise Thwaites

Abstract

Despite long-standing availability of an effective vaccine, tetanus remains a significant problem in many countries. Outcome depends on access to mechanical ventilation and intensive care facilities and in settings where these are limited, mortality remains high. Administration of tetanus antitoxin by the intramuscular route is recommended treatment for tetanus, but as the tetanus toxin acts within the central nervous system, it has been suggested that intrathecal administration of antitoxin may be beneficial. Previous studies have indicated benefit, but with the exception of one small trial no blinded studies have been performed. The objective of this study is to establish whether the addition of intrathecal tetanus antitoxin reduces the need for mechanical ventilation in patients with tetanus. Secondary objectives: to determine whether the addition of intrathecal tetanus antitoxin reduces autonomic nervous system dysfunction and length of hospital/ intensive care unit stay; whether the addition of intrathecal tetanus antitoxin in the treatment of tetanus is safe and cost-effective; to provide data to inform recommendation of human rather than equine antitoxin. This study will enroll adult patients (≥16 years old) with tetanus...Continue Reading

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References

Aug 30, 1980·Lancet·P S GuptaB K Jain
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·P P ThomasM Mathew
Mar 1, 1994·Journal of Veterinary Internal Medicine·S L GreenL L Smith-Maxie
May 12, 2001·Tropical Medicine & International Health : TM & IH·J L BarlowC R Newton
Mar 9, 2004·BMJ : British Medical Journal·Demócrito de Barros Miranda-FilhoValéria Maria Gonçalves Albuquerque
Sep 15, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·C Louise ThwaitesJeremy J Farrar
Mar 24, 2006·Tropical Medicine & International Health : TM & IH·C L ThwaitesJ J Farrar
Feb 1, 2007·Indian Journal of Pediatrics·M G GeetaLulu Mathews
Jun 1, 2006·Global Public Health·UNKNOWN Aceh Epidemiology Group
Aug 18, 2009·Pain·Alexander G MuntsJacobus J van Hilten
Dec 27, 2011·Transactions of the Royal Society of Tropical Medicine and Hygiene·Huynh Thi LoanChristopher M Parry
Apr 11, 2013·Journal of Medical Systems·S L TingY K Tse
Nov 29, 2013·Journal of Infection and Public Health·Manish NarangNidhi Choudhary
Jul 17, 2014·Critical Care : the Official Journal of the Critical Care Forum·Chaturaka RodrigoSenaka Rajapakse
Aug 20, 2016·Journal of the Neurological Sciences·Yohannes W WoldeamanuelWoubishet Woldeamanuel

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Citations

Dec 14, 2019·The American Journal of Tropical Medicine and Hygiene·Ha Thi Hai DuongLouise Thwaites
Apr 13, 2021·Current Opinion in Neurology·Bettina PfauslerRonny Beer
Sep 22, 2021·Wellcome Open Research·Nguyen Van HaoC Louise Thwaites

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Clinical Trials Mentioned

NCT02999815

Software Mentioned

R
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