Intrathecal injection of codeine, buprenorphine, tilidine, tramadol and nefopam depresses the tail-flick response in rats

European Journal of Pharmacology
G Bernatzky, I Jurna

Abstract

The effect of intrathecal (i.t.) injection of the analgesic agents, codeine, buprenorphine, tilidine and one of its metabolites, nortilidine, tramadol and nefopam, was determined in the tail-flick test performed on rats. ED50 values were derived from the dose-response lines. The relative potency ranking established from the ED50 values is buprenorphine (0.4 nM) greater than nortilidine (29 nM) = tramadol (26 nM) = nefopam (34 nM) greater than codeine (42 nM) greater than tilidine (118 nM). An i.t. injection of the opiate antagonist, naloxone (5 micrograms), prevented the antinociceptive effect of all analgesic agents administered at the highest dose tested. It is concluded that these analgesic agents, like morphine, exert their effect at least in part through a spinal site of action.

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Citations

Jun 1, 1988·Der Schmerz·I Jurna
Jul 2, 1987·European Journal of Pharmacology·K H Carlsson, I Jurna
Aug 22, 2013·International Journal of Obstetric Anesthesia·A SubediK Pokharel
Apr 1, 1993·Anaesthesia·A E Delilkan, R Vijayan
Apr 1, 1994·British Journal of Clinical Pharmacology·T HummelG Kobal
Jul 21, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·José De AndrésAna Mínguez
Apr 14, 2010·Anaesthesia·M D Wiles, M H Nathanson
Aug 9, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Gurkan TurkerGulsen Korfali
Jan 8, 2004·The Journal of International Medical Research·S OzkanM Gökben
Sep 19, 2017·Expert Opinion on Drug Discovery·Lidia BravoEsther Berrocoso
Sep 24, 2002·The Annals of Pharmacotherapy·Céline Villier, Michel P Mallaret

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