Intrathecal lidocaine prevents cardiovascular collapse and neurogenic pulmonary edema in a rat model of acute intracranial hypertension

Anesthesia and Analgesia
S R R HallM Hong

Abstract

Sympathetic hyperactivity during sudden intracranial hypertension leads to cardiovascular instability, myocardial dysfunction, and neurogenic pulmonary edema. Because spinal anesthesia is associated with sympatholysis, we investigated the protective effects of intrathecal lidocaine in a rodent model. Halothane-anesthetized rats were given a 10-microL intrathecal injection of saline (n = 10) or lidocaine 1% (n = 6). A subdural balloon catheter was inflated for 60 s to produce intracranial hypertension. Hemodynamics were monitored, and hearts and lungs were harvested for histological examination. In Saline versus Lidocaine-Treated rats, peak mean arterial blood pressure during balloon inflation was 115 +/- 4 mm Hg versus 78 +/- 8 mm Hg (P < 0.05), mean arterial blood pressure 30 min after balloon deflation was 47 +/- 2 mm Hg versus 67 +/- 3 mm Hg (P < 0.05), and lung weight was 1.54 +/- 0.03 g versus 1.41 +/- 0.04 g (P < 0.05), respectively. Cardiac dysrhythmias and electrocardiographic changes were more frequent in the Saline-Treated group (P < 0.05). Saline-Treated rats had extensive, hemorrhagic pulmonary edema, whereas the Lidocaine-Treated rats had only patchy areas of lung abnormality. Histological changes in the myocardium...Continue Reading

References

Jan 1, 1987·Pharmacology, Biochemistry, and Behavior·C W LoomisF W Cervenko
Nov 1, 1983·The Journal of Trauma·R C MackersieF R Lewis

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Citations

Nov 24, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S R R HallM Hong
Jul 18, 2008·Anesthesia and Analgesia·Motoi KumagaiYoshitugu Tobe
Jun 28, 2003·Transplantation·Vassilios S AvlonitisJohn H Dark
Jan 10, 2006·Arquivos de neuro-psiquiatria·Manoel Baldoino Leal FilhoJosé Antonio Rocha Gontijo
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kanat OzisikKamer Kilinc
Jan 22, 2014·The Kaohsiung Journal of Medical Sciences·Yao LuChunshan Dong
Dec 17, 2014·Journal of Neurotrauma·Jiří ŠedýJosef Zicha
Dec 3, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Sean R R HallMurray Hong
Dec 15, 2020·The American Journal of Emergency Medicine·Edward Lo-CaoAndreas Fahlström
Aug 3, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie ZhaoBao-Ping Tian

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