PMID: 7992919Dec 1, 1994Paper

Intrathecal magnesium sulfate protects the spinal cord from ischemic injury during thoracic aortic cross-clamping

Anesthesiology
J I SimpsonG Koski

Abstract

Paraplegia is a known complication after surgery on the descending thoracic aorta. Thoracic aortic cross-clamping causes an increase in proximal aortic and cerebrospinal fluid pressures. Sodium nitroprusside, though effectively decreasing proximal aortic pressure, has been implicated in worsening the incidence of paraplegia by further increasing cerebrospinal fluid pressure and decreasing distal blood pressure, thereby reducing spinal cord perfusion pressure. Intravenous administration of magnesium sulfate has been shown to offer some spinal cord protection when used with mild hypothermia. This study investigated the effect of intrathecal magnesium on the prevention of paraplegia when sodium nitroprusside is used to control proximal hypertension during thoracic aortic cross-clamping in a dog model of spinal cord ischemia. Two groups of eight dogs underwent thoracic aortic cross-clamping via a small thoracotomy incision for 45 min. Proximal, distal, and central venous pressures and cerebrospinal fluid pressures were monitored. Temperature was maintained at 36 degrees C. Sodium nitroprusside was used to control proximal hypertension. The control group received no magnesium sulfate, and a second group received 3 mg/kg intrathecal ...Continue Reading

Citations

Jun 7, 2005·International Journal of Obstetric Anesthesia·D D Doblar, S D Schumacher
May 9, 2007·Annals of Vascular Surgery·Hiroki KohnoMasaru Miyazaki
Jun 22, 2016·Drug Discovery Today·Raffaele NardoneJohann Sellner

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