PMID: 9174236Apr 1, 1997Paper

Intrathecal methotrexate overdose

Acta Paediatrica
A C LeeK T So

Abstract

We report two cases of intrathecal methotrexate overdose. A 3-y-old girl with acute lymphoblastic leukaemia and a 4-y-old boy with Burkitt's lymphoma were to receive an intrathecal injection of methotrexate after completion of intravenous methotrexate infusion. Instead of 12.5 mg, they both received a dose of 125 mg. Both children developed generalized convulsion 3 h after the overdose, but afterwards recovered completely. Intravenous folinic acid and dexamethasone rescue were employed, but no attempt was made to exchange the cerebrospinal fluid. In addition to the staff's failure to check the drug label carefully, the marked resemblance of the two dose preparations of methotrexate (50 mg/5 ml and 500 mg/5 ml) may have been contributory.

References

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Citations

Dec 30, 1983·The American Journal of Medicine·R T Hoffmeister
Oct 1, 1990·The Journal of Nutritional Biochemistry·E A PomfretS H Zeisel
Mar 17, 2004·Neurotoxicology·Yoram FinkelsteinMoshe Hersch
Jan 16, 1999·Pediatric Clinics of North America·M Grossi
Feb 14, 2002·British Journal of Haematology·Jonathan AllardSuzette Woodward
May 1, 2005·Environmental Toxicology and Pharmacology·Yoram FinkelsteinYedidia Bentur
May 4, 2010·Journal of Chemotherapy·M ScalzoneR Riccardi
Apr 23, 2013·The Annals of Pharmacotherapy·Rachel ThienprayoonDaniel C Bowers
Oct 20, 2004·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Daniel J FranceJames A Whitlock
Jun 16, 2019·Cancers·Silvia TriaricoAntonio Ruggiero
Nov 10, 2013·Cancer Nursing·Peter J Gilbar
Nov 5, 2002·Annual Review of Entomology·Andrej Cokl, Meta Virant-Doberlet
Jul 25, 2019·American Journal of Pharmaceutical Education·Donald R Miller, Stefanie J Jangula

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