PMID: 6399986Jan 1, 1984Paper

Intrathecal methotrexate versus central nervous system leukemia

Cancer Drug Delivery
W A Bleyer

Abstract

This article summarizes studies conducted in children with acute lymphoblastic leukemia (ALL) who received intrathecal methotrexate (IT MTX) to prevent or treat central nervous system (CNS) leukemia. To better understand the pharmacologic requirements of intrathecal chemotherapy directed against CNS leukemia, this report begins with a review of the pathophysiology of CNS leukemia and the clinical aspects of this disease manifestation that influence IT MTX therapy. The pharmacokinetics of IT MTX are then presented and the review is concluded with observations on the importance of the dosage regimen.

References

Aug 5, 1972·British Medical Journal·R J WestM C Pike
May 1, 1983·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A BleyerD R Miller

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Citations

Jun 1, 1975·Journal of the Neurological Sciences·Y MichotteD L Massart
May 1, 1987·Seminars in Oncology Nursing·J Lind, N J Bush
Aug 1, 1995·Critical Reviews in Oncology/hematology·S L Berg, D G Poplack
Jan 4, 1998·Journal of Pediatric Hematology/oncology·W A BleyerB A Kamen
Mar 2, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Eric A SeemannMegan R White
Jun 14, 2012·Pediatric Blood & Cancer·Sue RichardsUNKNOWN Childhood Acute Lymphoblastic Leukemia Collaborative Group (CALLCG)
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M ClarkeUNKNOWN Childhood ALL Collaborative Group
May 24, 2017·Leukemia & Lymphoma·Richard A Larson

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