Intrathecal Morphine Administration Does Not Affect Survival After Liver Resection for Hepatocellular Carcinoma

Seminars in Cardiothoracic and Vascular Anesthesia
Natalie K SmithJeron Zerillo

Abstract

Opioids may influence tumor recurrence and cancer-free survival in hepatocellular carcinoma (HCC). The relationship between intrathecal morphine administration, tumor recurrence, and patient survival after hepatectomy for HCC is unknown. This single-center, retrospective study included 1837 liver resections between July 2002 and December 2012; 410 cases were incorporated in the final univariate and multivariate analysis. Confirmatory propensity matching yielded 65 matched pairs (intrathecal morphine vs none). Primary outcomes were recurrence of HCC and survival. Secondary outcomes included characterization of factors associated with recurrence and survival. Groups were similar except for increased coronary artery disease in the no intrathecal morphine group. All patients received volatile anesthesia. Compared with no intrathecal morphine (N = 307), intrathecal morphine (N = 103) was associated with decreased intraoperative intravenous morphine administration (median difference = 12.5 mg; 95% confidence interval [CI] = 5-20 mg). There was no difference in blood loss, transfusion, 3- or 5-year survival, or recurrence in the univariate analysis. Multivariate analysis identified covariates that significantly correlated with 5-year ...Continue Reading

References

Sep 29, 2006·Anesthesiology·Aristomenis K ExadaktylosDaniel I Sessler
Mar 28, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Justin Sangwook KoJae Won Joh
Jul 8, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hiroaki ShibaKatsuhiko Yanaga
Sep 9, 2009·Journal of Pain and Symptom Management·Philip E ShaheenRuth L Lagman
Nov 17, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ban C H TsuiBrendan T Finucane
May 27, 2010·Anesthesia and Analgesia·James G Bovill
May 29, 2010·Anesthesiology·Antje GottschalkEdward C Nemergut
Jul 16, 2010·British Journal of Anaesthesia·G L Snyder, S Greenberg
Mar 29, 2011·The American Journal of the Medical Sciences·Kuan-Fu LiaoYi-Ying Lin
Mar 31, 2011·BMJ : British Medical Journal·Paul S MylesUNKNOWN ANZCA Trials Group Investigators
Sep 29, 2011·European Journal of Anaesthesiology·Patrice ForgetMarc De Kock
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Jul 17, 2012·Journal of Opioid Management·Borja Mugabure BujedoAmaia Uría Azpiazu
Sep 25, 2012·Pain Research and Treatment·Borja Mugabure Bujedo
Jan 4, 2013·British Journal of Anaesthesia·A Heaney, D J Buggy
Apr 27, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·M BinczakC Jayr
Jan 29, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ramanathan KasivisvanathanSusan V Mallett
Apr 25, 2014·Current Opinion in Supportive and Palliative Care·Rohit Juneja
Aug 12, 2014·British Journal of Anaesthesia·D J BuggyP Singleton
Oct 7, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Linda Le-WendlingXavier Capdevila
Dec 23, 2015·The Journal of International Medical Research·Hyun-Chang KimDeok Man Hong
Mar 17, 2016·World Journal of Gastrointestinal Surgery·Raphael Lc AraujoWellington Andraus

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Citations

Feb 26, 2020·Current Treatment Options in Oncology·Jaya Amaram-DavilaAkhila Reddy
Aug 14, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Jiapeng HuangNathaen Weitzel
May 4, 2021·Current Opinion in Anaesthesiology·Julia DubowitzBernhard Riedel

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BETA
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