Intrathecal morphine provides effective and safe analgesia in children after cardiac surgery

Acta Anaesthesiologica Scandinavica
P K SuominenR L Eyres

Abstract

The purpose of this prospective, randomized, blinded to observer study was to assess the analgesic effect and safety of intrathecal morphine (ITM) in post-operative pain control in children after heart surgery with a sternotomy incision. Eighty children, 3-55 kg in body weight, undergoing elective cardiac surgery with opioid-based anaesthesia were randomly divided into two treatment groups to receive either 20 micrograms/kg ITM at induction of anaesthesia or control. To standardize the protocol for administration of post-operative rescue intravenous morphine boluses and infusion (20-60 micrograms/kg/h), the Cardiac Analgesic Assessment Scale (CAAS) was used. Nine patients were excluded from the study after randomization. Thirty-five patients were enrolled to the ITM group and 36 to the control group. The groups were similar for demographics and intra-operative clinical characteristics. The mean time for the first intravenous morphine dose from ITM administration or equivalent time zero in the control group was significantly longer (P = 0.003) in the ITM group compared with the control group (12.3 vs. 8.7 h). Time from Paediatric Intensive Care Unit (PICU) admission to the start of intravenous morphine was also significantly lon...Continue Reading

References

Jan 1, 1990·Clinical Pediatrics·J D TobiasM Solca
Mar 1, 1988·Anesthesia and Analgesia·G S VanstrumR Ilko
May 1, 1988·British Journal of Anaesthesia·G J Fitzpatrick, D C Moriarty
Sep 1, 1984·Anesthesiology·M J Cousins, L E Mather
Feb 1, 1984·British Journal of Anaesthesia·S E JonesG Hall-Davies
Dec 1, 1994·Anesthesia and Analgesia·E P VandermeulenJ Vermylen
Jul 1, 1993·Anesthesiology·P L BaileyT H Stanley
Aug 1, 1996·Anesthesia and Analgesia·M A ChaneyS Slogoff
Feb 1, 1997·Anesthesia and Analgesia·M A ChaneyS Slogoff
Apr 29, 1998·Paediatric Anaesthesia·M Goodarzi
May 24, 2000·Intensive Care Medicine·B De JongheH Outin
Jun 1, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R HallR McLaren
Sep 28, 2001·British Journal of Anaesthesia·N MasonF Bonnet
Jan 22, 2003·Paediatric Anaesthesia·Julia C FinkelAisling M Conran

❮ Previous
Next ❯

Citations

Dec 14, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Menachem M WeinerAlexander J C Mittnacht
Nov 3, 2010·Best Practice & Research. Clinical Anaesthesiology·Geoff Frawley, Pablo Ingelmo
Jun 29, 2007·Paediatric Anaesthesia·Tina Hoff Duedahl, Ebba Holme Hansen
May 28, 2008·Paediatric Anaesthesia·Richard HowardUNKNOWN Association of Paediatric Anaesthetists of Great Britain and Ireland
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Jan 25, 2011·Expert Opinion on Pharmacotherapy·Wai Yin MakTheresa Hui
Apr 26, 2018·World Journal for Pediatric & Congenital Heart Surgery·Uri Pollak, Alain Serraf
Mar 13, 2019·Paediatric Anaesthesia·Naveen Raj

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.