PMID: 9428901Jan 16, 1998Paper

Intrathecal morphine pump as a treatment option in chronic pain of nonmalignant origin

Surgical Neurology
I F AngelM E Carey

Abstract

Implantable pumps for the delivery of intrathecal morphine have become a common option for administering opiate medication for the management of pain in patients with terminal cancer. Options for treating chronic pain of non-malignant origin are more controversial. This study describes responses to intrathecal morphine administration for managing chronic pain in patients without an underlying malignancy. Eleven patients between the ages of 29 and 81 years, nine with failed back syndrome (FBS) and two with neuropathic pain (NP) from other causes, were chosen from 15 consecutive individuals referred to neurosurgery clinic. The presenting levels of pain and a functional-economic outcome level were determined for each patient. Patients were admitted to the hospital for therapeutic trials and were assessed for the appropriateness of their analgesic response and for adverse responses to the medication. A morphine pump was implanted in five males and six females who were followed for up to 3 years. A good to excellent analgesic response was seen in 8 (73%) patients (6 FBS; 2 NP). In the remaining three patients (27%), the analgesic response was judged poor (3 FBS). In patients with FBS, the total effective response was 67%. Two patien...Continue Reading

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Citations

Aug 16, 2000·Advanced Drug Delivery Reviews·M S Shoichet, S R Winn
Sep 16, 2000·Journal of Pain and Symptom Management·G BennettT Yaksh
Feb 3, 2000·Journal of the American College of Surgeons·W Kaakaji, K J Burchiel
Jul 1, 2002·Neuromodulation : Journal of the International Neuromodulation Society·Manuel Juliá NarváezBernarda Márquez Márquez
Jul 1, 2002·Neuromodulation : Journal of the International Neuromodulation Society·Maria Luisa Franco Gay
Dec 13, 2006·Pain Practice : the Official Journal of World Institute of Pain·Eric DominguezPrithvi Raj
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Jan 1, 2007·Neuromodulation : Journal of the International Neuromodulation Society·Sumeet VaderaAshwini D Sharan
Oct 31, 2012·International Journal of General Medicine·Monica TontodonatiGiustino Parruti
May 25, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Aysel AtliJohn D Loeser
Apr 22, 2004·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·J D Bartleson
Dec 7, 2007·Anesthesiology Clinics·Steven P Cohen, Anthony Dragovich
Aug 1, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Maged HamzaJessica Ketchum
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May 29, 2012·Pain Practice : the Official Journal of World Institute of Pain·George MiljanichMichael Saulino
Oct 22, 2003·Neurosurgery Clinics of North America·Richard K Simpson
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Jan 8, 2008·Journal of Pain and Symptom Management·Meredith NobleKaren Schoelles

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