PMID: 6170895Sep 1, 1981Paper

Intrathecal substance P depresses the tail-flick response - antagonism by naloxone

Naunyn-Schmiedeberg's Archives of Pharmacology
T Doi, I Jurna

Abstract

Substance P injected into the lumbar subarachnoid space of rats depressed the tail-flick response to radiant heat in a dose-dependent way. The effective doses ranged from 0.1 microgram to 100 micrograms per rat (ED 50: 1.5 microgram/rat). The maximum of the effect was reached 20 min after intrathecal injection and the effect lasted for about 30 min. An antinociceptive effect was also observed after intrathecal injection of substance P 1 microgram to spinal rats. The depression of the tail-flick response produced by intrathecal administration of substance P was abolished by intrathecal (5 micrograms/rat) or i.p. (0.5 mg/kg) injections of naloxone.

References

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Citations

Jan 1, 1988·Experimental Brain Research·P MasonR Maciewicz
Jul 31, 1985·European Journal of Pharmacology·C Post, K Folkers
Oct 18, 1988·European Journal of Pharmacology·A NakamuraH Shiomi
Feb 7, 1991·European Journal of Pharmacology·S Z LeiG L Wilcox
Apr 16, 1993·Neuroscience Letters·J KameiY Kasuya
Jan 12, 1993·Neuroscience Letters·J KameiY Kasuya
May 4, 1999·European Journal of Pharmacology·T SakuradaS Sakurada
Nov 1, 1987·Pain·D Papir-KricheliM Devor
Sep 1, 1989·Pain·Kenneth E McCarson, Barry D Goldstein
Aug 3, 2002·The Journal of Social Psychology·Maxim Voronov, Jefferson A Singer

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