Intrathecal synthesis of interleukin-2 and soluble IL-2 receptor in asymptomatic HIV-1 seropositive individuals. Correlation with local production of specific IgM and IgG antibodies

Journal of the Neurological Sciences
M CiardiA Cirelli

Abstract

The relationship between the interleukin-2 (IL-2) system and the humoral response against human immunodeficiency virus type-I (HIV-1) is important in understanding the immune reaction before the development of AIDS. Levels of IL-2 and soluble IL-2 receptor (sIL-2R) in serum and cerebrospinal fluid (CSF) samples from 31 asymptomatic HIV-1 seropositive individuals were measured and correlated with levels of anti-1 IgG and IgM antibodies. High IL-2 levels were detected in the CSF of 20 (65%) subjects, 18 (90%) of whom had evidence of intrathecal synthesis of HIV-1-specific IgM antibodies. Similarly, IgG antibodies were detected in 10 subjects who had elevated IL-2 levels in the CSF. Moreover, intrathecal levels of IL-2 and sIL-2R correlated with intrathecal synthesis of both IgG and IgM antibodies. Local release of IL-2 seems to play an important role in the initiation of the antibody response against HIV-1 in early stages of infection and may be utilised in devising effective therapeutic strategies.

References

Feb 14, 1992·Journal of Immunological Methods·M K ShariefE J Thompson
Apr 1, 1992·Annals of Neurology·W R TyorD E Griffin
Sep 1, 1991·The Journal of Clinical Investigation·J B Splawski, P E Lipsky
Nov 1, 1990·Journal of the Neurological Sciences·F LolliF Pinto
Jun 12, 1990·Journal of Immunological Methods·M K Sharief, E J Thompson
Feb 11, 1989·Lancet·P L LantosJ R Tighe
Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
Apr 1, 1988·Brain : a Journal of Neurology·F GrayF Scaravilli
Nov 1, 1984·The Journal of Experimental Medicine·T A WaldmannW C Greene
Jun 1, 1983·The Journal of Infectious Diseases·G P RiceM B Oldstone

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.