Intrathecal thiotepa: reappraisal of an established therapy

Journal of Pediatric Hematology/oncology
Paul G FisherDavid N Korones


Intrathecal thiotepa is recommended as a treatment of leptomeningeal metastases (LM) in children, although published data to support this approach are limited. The authors sought to determine the efficacy of intrathecal thiotepa for pediatric LM. The authors reviewed all children treated with intrathecal thiotepa for LM at two tertiary children's hospitals, assessing outcome by cerebrospinal fluid cytology, neuroimaging, neurologic examination, and overall survival rate. Fifteen children with LM evidenced by malignant cells in the cerebrospinal fluid (mean age 7.3 years; five medulloblastoma, one anaplastic astrocytoma, one glioblastoma, one retinoblastoma, one neuroblastoma, two rhabdomyosarcoma, one non-Hodgkin lymphoma, two acute lymphoblastic leukemia, and one acute myelogenous leukemia) were treated with intrathecal thiotepa at 5 to 11.5 mg/m2 per dose for two to seven doses. Five children received concomitant craniospinal irradiation; 12 received simultaneous systemic or other intrathecal chemotherapy, or both. Four children experienced clearance of malignant cells from the spinal fluid, but this response was sustained in only two. All four children with cytologic response received concurrent radiotherapy, chemotherapy, o...Continue Reading


May 1, 1995·Journal of Child Neurology·Marc C Chamberlain
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S A GrossmanD S Ettinger
Jan 1, 1997·Journal of Child Neurology·Marc C Chamberlain
Aug 8, 1998·Journal of Neuro-oncology·L M DeAngelis
Mar 15, 2001·Critical Reviews in Oncology/hematology·J Z KerrS M Blaney


Jun 5, 2012·Cancer Chemotherapy and Pharmacology·Michael P GabayJ Lee Villano
Apr 23, 2004·Current Neurology and Neuroscience Reports·Alexis Demopoulos
Apr 3, 2003·Current Treatment Options in Neurology·Catherine A. Mazzola, Ian F. Pollack
Jun 21, 2007·Current Treatment Options in Neurology·Carlos Rodriguez-GalindoMatthew W Wilson
Jul 5, 2007·Neurosurgical Focus·Robert Cavaliere, David Schiff
Feb 11, 2004·Cancer·Guillermo ChantadaEnrique Schvartzman
Jul 22, 2014·Veterinary and Comparative Oncology·S GenoniG B Cherubini
Aug 28, 2004·Expert Opinion on Pharmacotherapy·Terri S Armstrong, Mark R Gilbert
Jul 26, 2012·Hematology/oncology and Stem Cell Therapy·Imad JaradatAbdelatief Almousa
Sep 23, 2010·Journal of Neuro-oncology·Sonia PartapPaul G Fisher
Jun 16, 2019·Cancers·Silvia TriaricoAntonio Ruggiero
May 29, 2007·Journal of Neuro-oncology·Sucheta J VaidyaEric Bouffet

Related Concepts

Cerebrospinal Fluid
Combined Modality Therapy
Mixed Gliomas
Intrathecal Injection
Magnetization Transfer Contrast Imaging
Intracranial Meningeal Neoplasms
Neoplasm Recurrence, Local
TNM Staging System

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