Intrathecal urocortin I in the spinal cord as a murine model of stress hormone-induced musculoskeletal and tactile hyperalgesia

The European Journal of Neuroscience
A A LarsonKatalin J Kovács

Abstract

Stress is antinociceptive in some models of pain, but enhances musculoskeletal nociceptive responses in mice and muscle pain in patients with fibromyalgia syndrome. To test the hypothesis that urocortins are stress hormones that are sufficient to enhance tactile and musculoskeletal hyperalgesia, von Frey fibre sensitivity and grip force after injection of corticotropin-releasing factor (CRF), urocortin I and urocortin II were measured in mice. Urocortin I (a CRF1 and CRF2 receptor ligand) produced hyperalgesia in both assays when injected intrathecally (i.t.) but not intracerebroventricularly, and only at a large dose when injected peripherally, suggesting a spinal action. Morphine inhibited urocortin I-induced changes in nociceptive responses in a dose-related fashion, confirming that changes in behaviour reflect hyperalgesia rather than weakness. No tolerance developed to the effect of urocortin I (i.t.) when injected repeatedly, consistent with a potential to enhance pain chronically. Tactile hyperalgesia was inhibited by NBI-35965, a CRF1 receptor antagonist, but not astressin 2B, a CRF2 receptor antagonist. However, while urocortin I-induced decreases in grip force were not observed when co-administered i.t. with either NB...Continue Reading

References

Jan 1, 1985·Peptides·T NakazawaK Yamatsu
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R ChenW W Vale
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M PerrinW Vale
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W LovenbergT Oltersdorf
May 1, 1996·Clinical Rheumatology·A SivriB Sivri
Jan 1, 1997·Journal of Psychiatric Research·D J ClauwJ Bresette
Jul 16, 1999·The American Journal of Gastroenterology·A BartonD Marshall
Dec 22, 1999·Pain·W R Lariviere, R Melzack
Dec 22, 1999·The American Journal of Gastroenterology·A D SperberD Buskila
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·L QuinteroH Suarez-Roca
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·T M ReyesP E Sawchenko
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·K LewisW W Vale
Jan 12, 2002·Current Opinion in Pharmacology·Johannes M H M Reul, Florian Holsboer
Feb 7, 2002·Trends in Pharmacological Sciences·Frank M Dautzenberg, Richard L Hauger
Jul 9, 2002·The European Journal of Neuroscience·Marcel M van GaalenThomas Steckler
Feb 20, 2003·Brain Research·Luis QuinteroHeberto Suarez-Roca
Mar 13, 2003·Neuroscience Research·Iraci Lucena da Silva TorresMaria Beatriz C Ferreira
Aug 14, 2003·Trends in Pharmacological Sciences·Eric P ZorrillaGeorge F Koob
Aug 26, 2003·Advanced Drug Delivery Reviews·Carolyn A Fairbanks
Oct 8, 2004·Expert Opinion on Therapeutic Targets·Warren B Nothnick
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Masayuki SarutaHironobu Sasano
May 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M NijsenB Coulie
Oct 11, 2005·Behavioural Brain Research·Heberto Suarez-RocaLorena Pinerua-Shuhaibar
Oct 28, 2005·Mini Reviews in Medicinal Chemistry·Olaf JahnJoachim Spiess
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Nicole J Westphal, Audrey F Seasholtz
Apr 21, 2006·Physiology & Behavior·Heberto Suarez-RocaSrinivas G Rao
May 3, 2006·Peptides·G TelegdyG Tóth

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.