Intrathoracic and intraabdominal wall implantation of a centrifugal blood pump for circulatory assist

Artificial Organs
Y WakisakaH Takano

Abstract

An implantable centrifugal pump (ICP) 320 ml in volume and 830 g in weight has been developed for prolonged circulatory assist. The antithrombogenicity of the ICP is provided by a balancing hole in the center of the impeller. The watertightness and histocompatibility of the ICP are supported by its silicone ring seal and its casing of titanium and acrylic resin, respectively. The total efficiency of the ICP was 30% at a 5 L/min flow rate and a 100 mm Hg head. The heat generation, watertightness, and anatomical fitting of the ICP were assessed in an intrathoracic implantation in a goat (66 kg) and in an intraabdominal wall implantation in a goat (70 kg). Warfarin was given for anticoagulation in each experiment to keep the prothrombin time around 1.7 times that of the control. The temperatures of the pump surface, the pleura, and the room were measured every 3 h. Anatomical fitting was evaluated by pathological observation after the termination of the experiment. The ICP could run for 40 days in the chest cavity and for 11 days in the abdominal wall. The temperature of the motor remained about 1.8 degrees C higher than the reference in both experiments. The ICP was completely covered by a layer of smooth fibrous tissue. The mois...Continue Reading

References

Jul 1, 1994·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·C R DaviesH Harasaki
Jul 1, 1995·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Y WakisakaK Toda
Sep 1, 1996·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S KollaR H Bartlett
May 1, 1997·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·N MoazamiM C Oz

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Citations

Apr 2, 2004·Journal of Biomedical Materials Research. Part a·Stephen L HilbertVictor J Ferrans
Jan 30, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tomonori TsukiyaHisateru Takano
Sep 29, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·T TsukiyaH Takano

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