Abstract
Although an attractive alternative to daily insulin therapy, allogeneic pancreatic islet transplantation has yielded suboptimal results in clinical trials, in contrast to islet allotransplantation in animal models, which have demonstrated consistent success. The successful transplantation of isolated islets to the thymus, with a single concomitant dose of antilymphocyte serum, has been demonstrated in rodents, and more significantly, such intrathymic islet allografts have been shown to induce recipient tolerance toward subsequent extrathymic donor strain islet allografts. Intrathymic islet autotransplantation has been pursued, as a prelude to studies of allogeneic IT islet transplantation and tolerance induction, in canine, porcine, and non-human primate models, to assess the large animal thymus as a site capable of supporting a viable islet graft. However, little functional or histological evidence has established definitive survival of islets transplanted within the thymus of a phylogenetically advanced species, which may be requisite to tolerance induction. This study describes the successful intrathymic autotransplantation of isolated islets using a canine model. Purpose-bred juvenile dogs, aged 4-6 months, underwent partia...Continue Reading
References
Jan 1, 1977·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·V Mirkovitch, M Campiche
Mar 1, 1976·Transplantation·V Mirkovitch, M Campiche
Mar 30, 1991·Lancet·G RemuzziN Perico
Mar 1, 1991·Pancreas·C Ricordi
Jan 1, 1992·Transplantation·M VivesG Soldevila
Feb 1, 1992·Transplantation·C RicordiD H Mintz
Dec 1, 1991·Journal of the American Society of Nephrology : JASN·N PericoG Remuzzi
Aug 18, 1990·Lancet·A G TzakisT E Starzl
Sep 14, 1990·Science·A M PosseltA Naji
Apr 1, 1988·Transplantation·Z A LatifR Alejandro
Jan 1, 1989·Diabetes·L Jansson, S Sandler
Jan 1, 1989·Diabetes·S P LakeP R Bell
Nov 1, 1986·The Journal of Clinical Investigation·R AlejandroD H Mintz
Apr 1, 1988·Diabetes·C RicordiD W Scharp
Aug 1, 1985·Diabetes·R AlejandroD H Mintz
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
May 1, 1981·American Journal of Clinical Pathology·S M HsuH Fanger
Sep 1, 1984·The Journal of Surgical Research·L F Cobb, R C Merrell
Jul 1, 1995·The Journal of Surgical Research·N C ChowdhuryS F Oluwole
Aug 1, 1993·Transplantation·M H SayeghG Remuzzi
Nov 1, 1994·Diabetes·J H JuangG C Weir
Apr 1, 1994·The Journal of Surgical Research·P C WattE P Passaro
Dec 1, 1993·Transplantation·S F OluwoleM A Hardy
Mar 1, 1993·The Journal of Clinical Investigation·E MontañaG C Weir
Apr 1, 1993·Transplantation·L CamposA Naji
May 1, 1993·Transplantation·J S OdoricoC F Barker
Jun 1, 1997·Transplantation Proceedings·L NelsonJ Leone
Aug 1, 1997·Canadian Journal of Physiology and Pharmacology·R C Bell, D T Finegood
Dec 10, 1997·Diabetes·R AlejandroD H Mintz
Mar 31, 1998·Diabetes·A U TeuscherR P Robertson
Sep 2, 1998·Transplantation Proceedings·D E SutherlandR W Gruessner
Jul 27, 2000·The New England Journal of Medicine·A M ShapiroR V Rajotte
Apr 6, 2001·Diabetes·E A RyanA M Shapiro
Feb 1, 1964·The Journal of Clinical Endocrinology and Metabolism·J A MOORHOUSEN J ROSEN
Citations
Dec 24, 2008·Transplantation·Peter John HortonJeremy R Chapman
Dec 2, 2009·Transplantation·Ricardo Pujol-BorrellMaria Pilar Armengol
Jul 31, 2008·Endocrine Reviews·Xiaolun HuangKenneth L Brayman
Oct 10, 2013·Clinical & Developmental Immunology·Andrew R PepperA M James Shapiro
Jan 15, 2014·Current Problems in Surgery·Preeti Chhabra, Kenneth L Brayman
Nov 11, 2008·The British Journal of Surgery·S MeraniA M J Shapiro
Jan 25, 2013·Experimental Diabetes Research·Naoaki SakataMichiaki Unno
Jan 7, 2000·Journal of Clinical Anesthesia·N ManciuK G Belani
May 8, 2018·International Journal of Molecular Sciences·Naoaki SakataShohta Kodama
May 31, 2018·Current Opinion in Organ Transplantation·Andrew R PepperA M James Shapiro
Aug 26, 2018·Biotechnology and Bioengineering·Marcos Perez-BasterrecheaAlvaro J Obaya
May 23, 2006·Pharmacological Reviews·Ajit S Narang, Ram I Mahato
Oct 12, 2017·Transplantation·Satomi Suzuki UematsuMasafumi Goto
May 27, 2020·Transplantation·Kang XuTao Du