Intrathymic islet transplantation in the canine: I. Histological and functional evidence of autologous intrathymic islet engraftment and survival in pancreatectomized recipients

Transplantation
Mark M LevyKenneth L Brayman

Abstract

Although an attractive alternative to daily insulin therapy, allogeneic pancreatic islet transplantation has yielded suboptimal results in clinical trials, in contrast to islet allotransplantation in animal models, which have demonstrated consistent success. The successful transplantation of isolated islets to the thymus, with a single concomitant dose of antilymphocyte serum, has been demonstrated in rodents, and more significantly, such intrathymic islet allografts have been shown to induce recipient tolerance toward subsequent extrathymic donor strain islet allografts. Intrathymic islet autotransplantation has been pursued, as a prelude to studies of allogeneic IT islet transplantation and tolerance induction, in canine, porcine, and non-human primate models, to assess the large animal thymus as a site capable of supporting a viable islet graft. However, little functional or histological evidence has established definitive survival of islets transplanted within the thymus of a phylogenetically advanced species, which may be requisite to tolerance induction. This study describes the successful intrathymic autotransplantation of isolated islets using a canine model. Purpose-bred juvenile dogs, aged 4-6 months, underwent partia...Continue Reading

References

Jan 1, 1977·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·V Mirkovitch, M Campiche
Feb 1, 1992·Transplantation·C RicordiD H Mintz
Dec 1, 1991·Journal of the American Society of Nephrology : JASN·N PericoG Remuzzi
Apr 1, 1988·Transplantation·Z A LatifR Alejandro
Nov 1, 1986·The Journal of Clinical Investigation·R AlejandroD H Mintz
Apr 1, 1988·Diabetes·C RicordiD W Scharp
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Sep 1, 1984·The Journal of Surgical Research·L F Cobb, R C Merrell
Apr 1, 1994·The Journal of Surgical Research·P C WattE P Passaro
Jun 1, 1997·Transplantation Proceedings·L NelsonJ Leone
Aug 1, 1997·Canadian Journal of Physiology and Pharmacology·R C Bell, D T Finegood
Sep 2, 1998·Transplantation Proceedings·D E SutherlandR W Gruessner
Feb 1, 1964·The Journal of Clinical Endocrinology and Metabolism·J A MOORHOUSEN J ROSEN

❮ Previous
Next ❯

Citations

Dec 2, 2009·Transplantation·Ricardo Pujol-BorrellMaria Pilar Armengol
Oct 10, 2013·Clinical & Developmental Immunology·Andrew R PepperA M James Shapiro
Jan 15, 2014·Current Problems in Surgery·Preeti Chhabra, Kenneth L Brayman
Nov 11, 2008·The British Journal of Surgery·S MeraniA M J Shapiro
Jan 25, 2013·Experimental Diabetes Research·Naoaki SakataMichiaki Unno
Jan 7, 2000·Journal of Clinical Anesthesia·N ManciuK G Belani
May 8, 2018·International Journal of Molecular Sciences·Naoaki SakataShohta Kodama
May 31, 2018·Current Opinion in Organ Transplantation·Andrew R PepperA M James Shapiro
Aug 26, 2018·Biotechnology and Bioengineering·Marcos Perez-BasterrecheaAlvaro J Obaya
May 23, 2006·Pharmacological Reviews·Ajit S Narang, Ram I Mahato
May 27, 2020·Transplantation·Kang XuTao Du

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.